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Post-metaphase correction of aberrant kinetochore-microtubule attachments in mammalian eggs
Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden. itajima, Tomoya S..
KTH, School of Engineering Sciences (SCI), Applied Physics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-0578-4003
2019 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, article id e47905Article in journal (Refereed) Epub ahead of print
Abstract [en]

The accuracy of the two sequential meiotic divisions in oocytes is essential for creating a haploid gamete with a normal chromosomal content. Here, we have analysed the 3D dynamics of chromosomes during the second meiotic division in live mouse oocytes. We find that chromosomes form stable kinetochore-microtubule attachments at the end of prometaphase II stage that are retained until anaphase II onset. Remarkably, we observe that more than 20% of the kinetochore-microtubule attachments at the metaphase II stage are merotelic or lateral. However, II are found to lag at the spindle equator and < 10% of the laggards missegregate and give rise to aneuploid gametes. Our results demonstrate that aberrant kinetochore-microtubule attachments are not corrected at the metaphase stage of the second meiotic division. Thus, the accuracy of the chromosome segregation process in mouse oocytes during meiosis II is ensured by an efficient correction process acting at the anaphase stage.

Place, publisher, year, edition, pages
Wiley , 2019. article id e47905
Keywords [en]
aneuploidy, meiosis, oocyte, second meiotic division, segregation
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-255756DOI: 10.15252/embr.201947905ISI: 000477354000001PubMedID: 31290587Scopus ID: 2-s2.0-85068754789OAI: oai:DiVA.org:kth-255756DiVA, id: diva2:1342222
Note

QC 20190813

Available from: 2019-08-13 Created: 2019-08-13 Last updated: 2019-10-04Bibliographically approved

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Brismar, Hjalmar

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CiteExportLink to record
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Citation style
  • apa
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  • modern-language-association-8th-edition
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More styles
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