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Comparison of acquisition protocols for ventilation/perfusion SPECT - a Monte Carlo study.
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Medicinsk avbildning. (medicinsk bildbehandling och visualisering)ORCID-id: 0000-0002-7750-1917
Vise andre og tillknytning
2019 (engelsk)Inngår i: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

One of the most commonly used imaging techniques for diagnosing pulmonary embolism (PE) is ventilation/perfusion (V/P) scintigraphy. The aim of this study was to evaluate the performance of the currently used imaging protocols for V/P single photon emission computed tomography (V/P SPECT) at two nuclear medicine department sites and to investigate the effect of altering important protocol parameters. 
 
 The Monte Carlo technique was used to simulate 4D digital phantoms with perfusion defects. Six imaging protocols were included in the study and a total of 72 digital patients were simulated. Six dually trained radiologists/nuclear medicine physicians reviewed the images and reported all perfusion mismatch findings. The radiologists also visually graded the image quality. 
 
 No statistically significant differences in diagnostic performance were found between the studied protocols, but visual grading analysis pointed out one protocol as significantly superior to four of the other protocols. Considering the study results, we have decided to harmonize our clinical protocols for imaging patients with suspected PE. The administered Technegas and macro aggregated albumin activities have been altered, a low energy all purpose collimator is used instead of a low energy high resolution collimator and the acquisition times have been lowered.

sted, utgiver, år, opplag, sider
Institute of Physics (IOP), 2019.
Emneord [en]
Monte Carlo, SPECT, embolism, lung scintigraphy, perfusion, pulmonary, ventilation
HSV kategori
Forskningsprogram
Medicinsk teknologi
Identifikatorer
URN: urn:nbn:se:kth:diva-258727DOI: 10.1088/1361-6560/ab36eePubMedID: 31362272Scopus ID: 2-s2.0-85076197090OAI: oai:DiVA.org:kth-258727DiVA, id: diva2:1350105
Merknad

QC 20191105

Tilgjengelig fra: 2019-09-10 Laget: 2019-09-10 Sist oppdatert: 2020-03-09bibliografisk kontrollert

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