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Integration of a Droplet-Based Microfluidic System and Silicon Nanoribbon FET Sensor
KTH, School of Engineering Sciences (SCI), Applied Physics, Material Physics, MF.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.ORCID iD: 0000-0001-7510-0864
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Nano Biotechnology.ORCID iD: 0000-0001-5232-0805
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2016 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 7, no 134Article in journal (Refereed) Published
Abstract [en]

We present a novel microfluidic system that integrates droplet microfluidics with a silicon nanoribbon field-effect transistor (SiNR FET), and utilize this integrated system to sense differences in pH. The device allows for selective droplet transfer to a continuous water phase, actuated by dielectrophoresis, and subsequent detection of the pH level in the retrieved droplets by SiNR FETs on an electrical sensor chip. The integrated microfluidic system demonstrates a label-free detection method for droplet microfluidics, presenting an alternative to optical fluorescence detection. In this work, we were able to differentiate between droplet trains of one pH-unit difference. The pH-based detection method in our integrated system has the potential to be utilized in the detection of biochemical reactions that induce a pH-shift in the droplets.

Place, publisher, year, edition, pages
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, 2016. Vol. 7, no 134
Keywords [en]
Droplet microfluidics, Nano, FETPH measurement, Silicon nanoribbon
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:kth:diva-260570DOI: 10.3390/mi7080134ISI: 000382467700006PubMedID: 30404306Scopus ID: 2-s2.0-84984791952OAI: oai:DiVA.org:kth-260570DiVA, id: diva2:1355981
Note

QC 20191004

Available from: 2019-09-30 Created: 2019-09-30 Last updated: 2019-10-04Bibliographically approved

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