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Synovial fluid components as synergistic lubricants in articular joint models
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry.
2019 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Smörjningssynergier mellan komponenter i synovialvätska (Swedish)
Abstract [en]

The excellent lubrication present within mammalian synovial joints attracted scientific interest, and some close-to-realistic models were applied to study the mechanism in vitro. In this project, the synergistic lubrication of synovial fluid was investigated by using 1,2-Dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), hyaluronic acid (HA), and phosphate-buffered saline (PBS buffer) to mimic the synovial fluid. Lubrication by the model synovial fluid was studied using borosilicate glass specimens in Mini-Traction Machine (MTM). The experiments proved that the DPPC vesicle solution and mixed DPPC/HA solution had excellent lubrication ability, stemming both from adsorption of a lubricious layer at the surface of glass specimens and from presence of material reservoir available for repair of wear defects in the lubricious layer. Comparing the macroscale results obtained in this project by MTM with the results in previous studies on microscale by using AFM, we concluded that the microscale study of synergistic lubrication could predict macroscale results, even though some differences were detected due to limited possibilities for exact replication of experimental conditions at the two scales.

Place, publisher, year, edition, pages
2019. , p. 43
Keywords [en]
synergistic lubrication, synovial fluid, biolubrication, DPPC, hyaluronic acid, Mini-Traction Machine, macro- and microscale, profilometer
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-266374OAI: oai:DiVA.org:kth-266374DiVA, id: diva2:1384113
External cooperation
RISE
Educational program
Degree of Master - Molecular Science and Engineering
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Available from: 2020-01-09 Created: 2020-01-09 Last updated: 2020-01-09Bibliographically approved

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4243444546474845 of 112
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