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The effects of ZnO nanostructures of different morphology on bioenergetics and stress response biomarkers of the blue mussels Mytilus edulis
Univ Rostock, Inst Biol Sci, Dept Marine Biol, Rostock, Germany.;Ternopil V Hnatiuk Natl Pedagog Univ, Dept Human Hlth Phys Rehabil & Vital Act, Ternopol, Ukraine..
Univ Rostock, Inst Biol Sci, Dept Marine Biol, Rostock, Germany..
KTH, School of Engineering Sciences (SCI), Applied Physics, Materials and Nanophysics.ORCID iD: 0000-0002-1679-1316
Ternopil V Hnatiuk Natl Pedagog Univ, Dept Human Hlth Phys Rehabil & Vital Act, Ternopol, Ukraine..
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2019 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 694, article id UNSP 133717Article in journal (Refereed) Published
Abstract [en]

Biofouling causes massive economical losses in the maritime sector creating an urgent need for effective and ecologically non-harmful antifouling materials. Zinc oxide (ZnO) nanorod coatings show promise as an antifouling material; however, the toxicity of ZnO nanorods to marine organisms is not known. We compared the toxicity of suspended ZnO nanorods (NR) with that of ZnO nanoparticles (NP) and ionic Zn2+ in amarine bivalve Mytilus edulis exposed for two weeks to 10 or 100 mu g Zn L-1 of ZnO NPs, NRs or Zn2+, or to immobilized NRs. The multi-biomarker assessment included bioenergetics markers (tissue energy reserves, activity ofmitochondrial electron transport system and autophagic enzymes), expression of apoptotic and inflammatory genes, and general stress biomarkers (oxidative lesions, lysosomalmembrane stability and metallothionein expression). Exposure to ZnO NPs, NRs and Zn2+ caused accumulation of oxidative lesions in proteins and lipids, stimulated autophagy, and led to lysosomal membrane destabilization indicating toxicity. However, these responses were not specific for the form of Zn (NPs, NR or Zn2+) and showed no monotonous increase with increasing Zn concentrations in the experimental exposures. No major disturbance of the energy status was found in the mussels exposed to ZnO NPs, NRs, or Zn2+. Exposure to ZnO NPs and NRs led to a strong induction of apoptosis- and inflammation-related genes, which was not seen in Zn2+ exposures. Based on the integrated biomarker response, the overall toxicity as well as the pro-apoptotic and pro-inflammatory action was stronger in ZnO NPs compared with the NRs. Given the stability of ZnO NR coatings and the relatively low toxicity of suspended ZnO NR, ZnO NR coating might be considered a promising low-toxicity material for antifouling paints.

Place, publisher, year, edition, pages
ELSEVIER , 2019. Vol. 694, article id UNSP 133717
Keywords [en]
Nanomaterials, Biomarkers, Antifouling, Bioenergetics, Trace metals, Apoptosis, Inflammation, Oxidative stress, Metallothioneins
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:kth:diva-265213DOI: 10.1016/j.scitotenv.2019.133717ISI: 000496780900082PubMedID: 31400676Scopus ID: 2-s2.0-85073704563OAI: oai:DiVA.org:kth-265213DiVA, id: diva2:1420839
Note

QC 20200331

Available from: 2020-03-31 Created: 2020-03-31 Last updated: 2022-06-26Bibliographically approved

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Fei, YeDutta, Joydeep

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