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Abundance and diversity of resistomes differ between healthy human oral cavities and gut
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England..ORCID iD: 0000-0002-3038-8929
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England..ORCID iD: 0000-0002-7391-9371
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England..ORCID iD: 0000-0002-6428-5936
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH). Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England..ORCID iD: 0000-0001-5834-4533
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2020 (English)In: Nature Communications, E-ISSN 2041-1723, Vol. 11, no 1Article in journal (Refereed) Published
Abstract [en]

The global threat of antimicrobial resistance has driven the use of high-throughput sequencing techniques to monitor the profile of resistance genes, known as the resistome, in microbial populations. The human oral cavity contains a poorly explored reservoir of these genes. Here we analyse and compare the resistome profiles of 788 oral cavities worldwide with paired stool metagenomes. We find country and body site-specific differences in the prevalence of antimicrobial resistance genes, classes and mechanisms in oral and stool samples. Within individuals, the highest abundances of antimicrobial resistance genes are found in the oral cavity, but the oral cavity contains a lower diversity of resistance genes compared to the gut. Additionally, co-occurrence analysis shows contrasting ARG-species associations between saliva and stool samples. Maintenance and persistence of antimicrobial resistance is likely to vary across different body sites. Thus, we highlight the importance of characterising the resistome across body sites to uncover the antimicrobial resistance potential in the human body. Antimicrobial resistance (AMR) represents a global health threat. Here, the authors analyse the oral and gut resistomes from metagenomes of diverse populations and find that the oral resistome harbours higher abundance but lower diversity of antimicrobial resistance genes than the gut resistome.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2020. Vol. 11, no 1
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Biological Sciences
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URN: urn:nbn:se:kth:diva-273524DOI: 10.1038/s41467-020-14422-wISI: 000529522400001PubMedID: 32019923Scopus ID: 2-s2.0-85078913225OAI: oai:DiVA.org:kth-273524DiVA, id: diva2:1431082
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QC 20200519

Available from: 2020-05-19 Created: 2020-05-19 Last updated: 2024-03-15Bibliographically approved

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Lee, SunjaeShoaie, Saeed

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Carr, Victoria R.Witherden, Elizabeth A.Lee, SunjaeShoaie, SaeedGomez-Cabrero, David
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Science for Life Laboratory, SciLifeLabSchool of Engineering Sciences in Chemistry, Biotechnology and Health (CBH)
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