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Sensitivity Analysis of Mathematical Model to Study the Effect of T Cells Infusion in Treatment of CLL
Univ Engn & Technol, Dept Math, Lahore 54890, Pakistan.;Minhaj Univ, Dept Math, Lahore 54770, Pakistan..
KTH, Skolan för teknikvetenskap (SCI), Matematik (Inst.). Univ Hail, Fac Sci, Dept Math, Hail 81451, Saudi Arabia..
Univ Hail, Fac Sci, Dept Math, Hail 81451, Saudi Arabia..
2020 (Engelska)Ingår i: Mathematics, E-ISSN 2227-7390, Vol. 8, nr 4, artikel-id 564Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

In this paper, we considered a mathematical model concerned with the treatment of Chronic Lymphocytic Leukemia (CLL) taking into account the effect of superficially infused T cells in this particular type of tumor. The model is described thoroughly by the system of non-linear differential equations explaining the interaction of naive, infected, cancer and immune cell population. The detailed sensitivity analysis with the application is the major part of this paper. The basic objective is to provide insight to how parameters' behavior varies model results by elaborating the results obtained from the application of sensitivity analysis. The sensitivity of the model was evaluated not only theoretically, but also with the help of a numerical approach, producing graphs providing better imminent of results. We argue that the application of the sensitivity analysis method endows an insight into how and which parameters are of primary significance in controlling the spread of leukemia.

Ort, förlag, år, upplaga, sidor
MDPI AG , 2020. Vol. 8, nr 4, artikel-id 564
Nyckelord [en]
sensitivity analysis, chronic lymphocytic leukemia, immune response, mathematical modeling, T cells
Nationell ämneskategori
Matematik
Identifikatorer
URN: urn:nbn:se:kth:diva-273907DOI: 10.3390/math8040564ISI: 000531824100104Scopus ID: 2-s2.0-85084478437OAI: oai:DiVA.org:kth-273907DiVA, id: diva2:1435586
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QC 20200605

Tillgänglig från: 2020-06-05 Skapad: 2020-06-05 Senast uppdaterad: 2022-06-26Bibliografiskt granskad

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Chaudhry, Qasim Ali
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