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Numerical Modeling and Investigation of Amperometric Biosensors with Perforated Membranes
Shahid Chamran Univ, Dept Mech Engn, Ahwaz 61355, Iran..
Shahid Chamran Univ, Dept Mech Engn, Ahwaz 61355, Iran..
Ton Duc Thang Univ, Metama Mech Biomech & Multiphys Applicat Res Grp, Ho Chi Minh City 758307, Vietnam.;Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City 758307, Vietnam..ORCID iD: 0000-0003-0965-2358
Shahid Chamran Univ, Dept Mech Engn, Ahwaz 61355, Iran..
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2020 (English)In: Sensors, E-ISSN 1424-8220, Vol. 20, no 10Article in journal (Refereed) Published
Abstract [en]

The present paper aims to investigate the influence of perforated membrane geometry on the performance of biosensors. For this purpose, a 2-D axisymmetric model of an amperometric biosensor is analyzed. The governing equations describing the reaction-diffusion equations containing a nonlinear term related to the Michaelis-Menten kinetics of the enzymatic reaction are introduced. The partial differential governing equations, along with the boundary conditions, are first non-dimensionalized by using appropriate dimensionless variables and then solved in a non-uniform unstructured grid by employing the Galerkin Finite Element Method. To examine the impact of the hole-geometry of the perforated membrane, seven different geometries-including cylindrical, upward circular cone, downward circular cone, upward paraboloid, downward paraboloid, upward concave paraboloid, and downward concave paraboloid-are studied. Moreover, the effects of the perforation level of the perforated membrane, the filling level of the enzyme on the transient and steady-state current of the biosensor, and the half-time response are presented. The results of the simulations show that the transient and steady-state current of the biosensor are affected by the geometry dramatically. Thus, the sensitivity of the biosensor can be influenced by different hole-geometries. The minimum and maximum output current can be obtained from the cylindrical and upward concave paraboloid holes. On the other hand, the least half-time response of the biosensor can be obtained in the cylindrical geometry.

Place, publisher, year, edition, pages
MDPI , 2020. Vol. 20, no 10
Keywords [en]
amperometric biosensor, biosensor current, finite element method, half-time response, mathematical model
National Category
Computational Mathematics
Identifiers
URN: urn:nbn:se:kth:diva-277703DOI: 10.3390/s20102910ISI: 000539323700164PubMedID: 32455593Scopus ID: 2-s2.0-85085274709OAI: oai:DiVA.org:kth-277703DiVA, id: diva2:1448787
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QC 20200629

Available from: 2020-06-29 Created: 2020-06-29 Last updated: 2022-06-26Bibliographically approved

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Saffari Pour, Mohsen

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