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Hydrolytic Degradation of Porous Crosslinked Poly(epsilon-Caprolactone) Synthesized by High Internal Phase Emulsion Templating
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology.ORCID iD: 0000-0002-3046-7547
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology. Univ Fed Rio Grande Sul UFRGS, Inst Chem, Dept Phys Chem, Av Bento Goncalves 9500, BR-91501970 Porto Alegre, RS, Brazil..ORCID iD: 0000-0003-1208-4013
Indian Inst Technol Delhi, Dept Text & Fibre Engn, New Delhi 110016, India..
Indian Inst Technol Delhi, Dept Text & Fibre Engn, New Delhi 110016, India..
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2020 (English)In: Polymers, E-ISSN 2073-4360, Vol. 12, no 8, article id 1849Article in journal (Refereed) Published
Abstract [en]

Porous poly(epsilon-caprolactone) (PCL) scaffolds were fabricated using the high internal polymerization emulsion (HIPE) technique. Bis(epsilon-caprolactone-4-yl) (BCY) was utilized as crosslinker. The crosslinking density and the volume fraction of the dispersed phase were varied in order to study the potential effect of these parameters on the hydrolytic degradation at 37 degrees C and 60 degrees C. After different hydrolysis times the remaining solid samples were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), while the degradation products in the aqueous aging solutions were analyzed by laser desorption ionization-mass spectrometry (LDI-MS). The effect of temperature on the degradation process and release of degradation products was, as expected, significant. The temperature effect was also shown by FTIR analysis that displayed a pronounced increase in the intensity of the hydroxyl-group absorption band after 70 days of hydrolysis at 60 degrees C indicating significant cleavage of the polymer chains. LDI-MS analysis proved the release of oligomers ranging from dimers to hexamers. The product patterns were similar, but the relativem/zsignal intensities increased with increasing time, temperature and crosslinking density, indicating larger amounts of released products. The latter is probably due to the decreasing degree of crystallinity as a function of amount of crosslinker. The porous structure and morphology of the scaffolds were lost during the aging. The higher the crosslinking density, the longer the scaffolds retained their original porous structure and morphology.

Place, publisher, year, edition, pages
MDPI AG , 2020. Vol. 12, no 8, article id 1849
Keywords [en]
polycaprolactone, high internal polymerization emulsion, hydrolytic degradation, scaffold
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-282246DOI: 10.3390/polym12081849ISI: 000568032800001PubMedID: 32824691Scopus ID: 2-s2.0-85090414317OAI: oai:DiVA.org:kth-282246DiVA, id: diva2:1489352
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QC 20201103

Available from: 2020-11-03 Created: 2020-11-03 Last updated: 2024-01-17Bibliographically approved

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Benyahia Erdal, NejlaLando, Gabriela AlbaraHakkarainen, Minna

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