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A high-stringency blueprint of the human proteome
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Centres, Albanova VinnExcellence Center for Protein Technology, ProNova. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Systems Biology.ORCID iD: 0000-0002-4858-8056
2020 (English)In: Nature Communications, E-ISSN 2041-1723, Vol. 11, no 1, article id 5301Article in journal (Refereed) Published
Abstract [en]

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases. The Human Proteome Project (HPP) was launched in 2010 to enhance accurate annotation of the genome-encoded proteome. Ten years later, the HPP releases its first blueprint of the human proteome, annotating 90% of all known proteins at high-stringency and discussing the implications of proteomics for precision medicine.

Place, publisher, year, edition, pages
NATURE RESEARCH , 2020. Vol. 11, no 1, article id 5301
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-286199DOI: 10.1038/s41467-020-19045-9ISI: 000582057600001PubMedID: 33067450Scopus ID: 2-s2.0-85092744472OAI: oai:DiVA.org:kth-286199DiVA, id: diva2:1523586
Note

QC 20210128

Available from: 2021-01-28 Created: 2021-01-28 Last updated: 2023-12-07Bibliographically approved

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Uhlén, Mathias

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