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On the Development of a Novel Contrast Pulse Sequence for Polymer-Shelled Microbubbles
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Medical Imaging.
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems. KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, S-14152 Stockholm, Sweden..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Medical Imaging.ORCID iD: 0000-0003-2589-9780
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Medical Imaging. Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey..ORCID iD: 0000-0003-4883-7347
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2021 (English)In: IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, ISSN 0885-3010, E-ISSN 1525-8955, Vol. 68, no 5, p. 1569-1579Article in journal (Refereed) Published
Abstract [en]

Contrast agents are routinely used in ultrasound examinations. Nonlinear ultrasound imaging techniques have been developed over decades to enhance the contrast between the tissue and the blood pool after the injection of ultrasound contrast agents (UCAs). In this study, we introduce a new contrast pulse sequence, CPS4. The CPS4 combines pulse inversion (PI), subharmonic (SH), and ultraharmonic (UH) techniques to remove propagation distortion while capturing the unique SH and UH responses from UCAs. The novel CPS4 and conventional PI, SH, and UH techniques were used to detect the presence of a research-grade, thick-shell, polymer microbubble in a tissue-mimicking flow phantom. The contrast-to-tissue ratios (CTRs) obtained from the applications of all techniques were compared. The results show that the highest CTR of approximately 16 dB was obtained using CPS4, which was superior to the individual reference techniques: PI, SH, and UH techniques, in all scenarios considered in this study.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE) , 2021. Vol. 68, no 5, p. 1569-1579
Keywords [en]
Ultrasonic imaging, Imaging, Transducers, Finite impulse response filters, Band-pass filters, Phantoms, Optical filters, Contrast pulse sequence, medical imaging, ultrasound contrast agents (UCAs)
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:kth:diva-296401DOI: 10.1109/TUFFC.2020.3041206ISI: 000645083300010PubMedID: 33245694Scopus ID: 2-s2.0-85104994503OAI: oai:DiVA.org:kth-296401DiVA, id: diva2:1565453
Note

QC 20210614

Available from: 2021-06-14 Created: 2021-06-14 Last updated: 2022-06-25Bibliographically approved

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Chen, HongjianEvangelou, DimitriosLoskutova, KseniaGhorbani, MortezaGrishenkov, Dmitry

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Chen, HongjianEvangelou, DimitriosLoskutova, KseniaGhorbani, MortezaGrishenkov, Dmitry
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IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
Medical Laboratory and Measurements Technologies

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