kth.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
Hallands Hosp Halmstad, Dept Pediat, Halmstad, Sweden.;Univ Gothenburg, Gothenburg Pediat Growth Res Ctr, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Wallenberg Lab,Dept Mol & Clin Med, Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Wallenberg Lab,Dept Mol & Clin Med, Gothenburg, Sweden.;Univ Wurzburg, Inst Mol Infect Biol, Wurzburg, Germany..
Chalmers Tekniska Hgsk, Dept Math Sci, Gothenburg, Sweden.;Univ Gothenburg, Inst Biomed, Dept Lab Med, Gothenburg, Sweden..
Show others and affiliations
2021 (English)In: Cell Host and Microbe, ISSN 1931-3128, E-ISSN 1934-6069, Vol. 29, no 5, p. 765-776.e3Article in journal (Refereed) Published
Abstract [en]

The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria are incorporated into the gut microbiota is still relatively unknown. Here, we analyze the microbiota from 471 Swedish children followed from birth to 5 years of age, collecting samples after 4 and 12 months and at 3 and 5 years of age as well as from their mothers at birth using 16S rRNA gene profiling. We also compare their microbiota to an adult Swedish population. Genera follow 4 different colonization patterns during establishment where Methanobrevibacter and Christensenellaceae colonize late and do not reached adult levels at 5 years. These late colonizers correlate with increased alpha diversity in both children and adults. By following the children through age-specific community types, we observe that children have individual dynamics in the gut microbiota development trajectory.

Place, publisher, year, edition, pages
Elsevier BV , 2021. Vol. 29, no 5, p. 765-776.e3
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:kth:diva-297817DOI: 10.1016/j.chom.2021.02.021ISI: 000653680400014PubMedID: 33794185Scopus ID: 2-s2.0-85105007642OAI: oai:DiVA.org:kth-297817DiVA, id: diva2:1571381
Note

QC 20210622

Available from: 2021-06-22 Created: 2021-06-22 Last updated: 2023-12-07Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Uhlén, Mathias

Search in DiVA

By author/editor
Simon, Marie-ChristineUhlén, MathiasGummesson, Anders
By organisation
Protein Science
In the same journal
Cell Host and Microbe
Microbiology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 28 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf