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Multifunctional 3D-Printed Wound Dressings
Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada..
Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada..
Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada..ORCID iD: 0000-0002-7406-0095
Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada..
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2021 (English)In: ACS Nano, ISSN 1936-0851, E-ISSN 1936-086X, Vol. 15, no 7, p. 12375-12387Article in journal (Refereed) Published
Abstract [en]

Personalized wound dressings provide enhanced healing for different wound types; however multicomponent wound dressings with discretely controllable delivery of different biologically active agents are yet to be developed. Here we report 3D-printed multicomponent biocomposite hydrogel wound dressings that have been selectively loaded with small molecules, metal nanoparticles, and proteins for independently controlled release at the wound site. Hydrogel wound dressings carrying antibacterial silver nanoparticles and vascular endothelial growth factor with predetermined release profiles were utilized to study the physiological response of the wound in a mouse model. Compared to controls, the application of dressings resulted in improvement in granulation tissue formation and differential levels of vascular density, dependent on the release profile of the growth factor. Our study demonstrates the versatility of the 3D-printed hydrogel dressings that can yield varied physiological responses in vivo and can further be adapted for personalized treatment of various wound types.

Place, publisher, year, edition, pages
American Chemical Society (ACS) , 2021. Vol. 15, no 7, p. 12375-12387
Keywords [en]
cellulose nanocrystals, nanocolloidal hydrogel, drug delivery, extrusion-based 3D printing, personalized wound care, wound dressing
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-300340DOI: 10.1021/acsnano.1c04499ISI: 000679406500124PubMedID: 34133121Scopus ID: 2-s2.0-85110135589OAI: oai:DiVA.org:kth-300340DiVA, id: diva2:1589808
Note

QC 20210901

Available from: 2021-09-01 Created: 2021-09-01 Last updated: 2024-03-15Bibliographically approved

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Mittal, Nitesh

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Chekini, MahshidMittal, NiteshKelley, Shana O.
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