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Multivalent glycoconjugates as anti-pathogenic agents
Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy.;Univ Milan, Ctr Eccellenza CISI, I-20133 Milan, Italy..ORCID iD: 0000-0002-1258-2007
CSIC, Ctr Invest Biol, Madrid 28040, Spain..ORCID iD: 0000-0001-5421-8513
Univ Parma, Dipartimento Chim, I-43100 Parma, Italy..ORCID iD: 0000-0001-9993-3262
Univ Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy..ORCID iD: 0000-0002-5147-1756
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2013 (English)In: Chemical Society Reviews, ISSN 0306-0012, E-ISSN 1460-4744, Vol. 42, no 11, p. 4709-4727Article, review/survey (Refereed) Published
Abstract [en]

Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.

Place, publisher, year, edition, pages
Royal Society of Chemistry (RSC) , 2013. Vol. 42, no 11, p. 4709-4727
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Microbiology in the medical area
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URN: urn:nbn:se:kth:diva-305700DOI: 10.1039/c2cs35408jISI: 000318791200012PubMedID: 23254759Scopus ID: 2-s2.0-84876740610OAI: oai:DiVA.org:kth-305700DiVA, id: diva2:1617239
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QC 20211206

Available from: 2021-12-06 Created: 2021-12-06 Last updated: 2022-06-25Bibliographically approved

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Lahmann, Martina

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Bernardi, AnnaJimenez-Barbero, JesusCasnati, AlessandroDe Castro, CristinaFieschi, FranckFinne, JukkaLahmann, MartinaMarradi, MarcoMessner, PaulMolinaro, AntonioMurphy, Paul V.Oscarson, StefanPeri, FrancescoPieters, Roland J.Renaudet, OlivierReymond, Jean-LouisRichichi, BarbaraRojo, JavierSansone, FrancescoTurnbull, W. BruceVelasco-Torrijos, TrinidadVidal, SebastienWennekes, TomZuilhof, HanImberty, Anne
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