kth.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Role of Cellular Metabolism during Candida-Host Interactions
Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England..
Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England..
Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England..
Kings Coll London, Fac Dent, Ctr Host Microbiome Interact, Oral & Craniofacial Sci, London, England..
Show others and affiliations
2022 (English)In: Pathogens, E-ISSN 2076-0817, Vol. 11, no 2, article id 184Article in journal (Refereed) Published
Abstract [en]

Microscopic fungi are widely present in the environment and, more importantly, are also an essential part of the human healthy mycobiota. However, many species can become pathogenic under certain circumstances, with Candida spp. being the most clinically relevant fungi. In recent years, the importance of metabolism and nutrient availability for fungi-host interactions have been highlighted. Upon activation, immune and other host cells reshape their metabolism to fulfil the energy-demanding process of generating an immune response. This includes macrophage upregulation of glucose uptake and processing via aerobic glycolysis. On the other side, Candida modulates its metabolic pathways to adapt to the usually hostile environment in the host, such as the lumen of phagolysosomes. Further understanding on metabolic interactions between host and fungal cells would potentially lead to novel/enhanced antifungal therapies to fight these infections. Therefore, this review paper focuses on how cellular metabolism, of both host cells and Candida, and the nutritional environment impact on the interplay between host and fungal cells.

Place, publisher, year, edition, pages
MDPI AG , 2022. Vol. 11, no 2, article id 184
Keywords [en]
immunometabolism, metabolism, macrophages, epithelial cells, glycolysis, glucose, moonlighting proteins, Candida albicans
National Category
Microbiology in the medical area Ecology
Identifiers
URN: urn:nbn:se:kth:diva-310586DOI: 10.3390/pathogens11020184ISI: 000771749300001PubMedID: 35215128Scopus ID: 2-s2.0-85123979623OAI: oai:DiVA.org:kth-310586DiVA, id: diva2:1649884
Note

QC 20220405

Available from: 2022-04-05 Created: 2022-04-05 Last updated: 2022-06-25Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Shoaie, Saeed

Search in DiVA

By author/editor
Shoaie, SaeedMoyes, David L.
By organisation
Science for Life Laboratory, SciLifeLabProtein Science
In the same journal
Pathogens
Microbiology in the medical areaEcology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 3 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf