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The Wittig bioconjugation of maleimide derived, water soluble phosphonium ylides to aldehyde-tagged proteins
KTH, School of Biotechnology (BIO), Centres, Albanova VinnExcellence Center for Protein Technology, ProNova. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Protein Technology.ORCID iD: 0000-0002-6104-6446
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2021 (English)In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 19, no 47, p. 10417-10423Article in journal (Refereed) Published
Abstract [en]

Herein we disclose the transformation of maleimides into water-soluble tris(2-carboxyethyl)phosphonium ylides and their subsequent application in the bioconjugation of protein- and peptide-linked aldehydes. The new entry into Wittig bioconjugate chemistry proceeds under mild conditions and relies on highly water soluble reagents, which are likely already part of most biochemists' inventory. 

Place, publisher, year, edition, pages
Royal Society of Chemistry (RSC) , 2021. Vol. 19, no 47, p. 10417-10423
Keywords [en]
Proteins, Bio-conjugation, Bioconjugates, Condition, Maleimides, Soluble reagents, Tagged proteins, Watersoluble, Aldehydes, maleimide, maleimide derivative
National Category
Organic Chemistry Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:kth:diva-313842DOI: 10.1039/d1ob01155cISI: 000721936100001PubMedID: 34817496Scopus ID: 2-s2.0-85121137061OAI: oai:DiVA.org:kth-313842DiVA, id: diva2:1668430
Note

QC 20220613

Available from: 2022-06-13 Created: 2022-06-13 Last updated: 2022-06-25Bibliographically approved

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Nilvebrant, JohanNygren, Per-Åke

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