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Integrative functional analysis uncovers metabolic differences between Candida species
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England..
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England..
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England..
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England..
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2022 (English)In: Communications Biology, E-ISSN 2399-3642, Vol. 5, no 1, article id 1013Article in journal (Refereed) Published
Abstract [en]

Metabolic differences between Candida species are uncovered using the BioFung database alongside genomic and metabolic analysis. Candida species are a dominant constituent of the human mycobiome and associated with the development of several diseases. Understanding the Candida species metabolism could provide key insights into their ability to cause pathogenesis. Here, we have developed the BioFung database, providing an efficient annotation of protein-encoding genes. Along, with BioFung, using carbohydrate-active enzyme (CAZymes) analysis, we have uncovered core and accessory features across Candida species demonstrating plasticity, adaption to the environment and acquired features. We show a greater importance of amino acid metabolism, as functional analysis revealed that all Candida species can employ amino acid metabolism. However, metabolomics revealed that only a specific cluster of species (AGAu species-C. albicans, C. glabrata and C. auris) utilised amino acid metabolism including arginine, cysteine, and methionine metabolism potentially improving their competitive fitness in pathogenesis. We further identified critical metabolic pathways in the AGAu cluster with biomarkers and anti-fungal target potential in the CAZyme profile, polyamine, choline and fatty acid biosynthesis pathways. This study, combining genomic analysis, and validation with gene expression and metabolomics, highlights the metabolic diversity with AGAu species that underlies their remarkable ability to dominate they mycobiome and cause disease.

Place, publisher, year, edition, pages
Springer Nature , 2022. Vol. 5, no 1, article id 1013
National Category
Microbiology Cancer and Oncology Microbiology in the medical area
Identifiers
URN: urn:nbn:se:kth:diva-319837DOI: 10.1038/s42003-022-03955-zISI: 000859940800002PubMedID: 36163459Scopus ID: 2-s2.0-85138662305OAI: oai:DiVA.org:kth-319837DiVA, id: diva2:1702628
Note

QC 20221011

Available from: 2022-10-11 Created: 2022-10-11 Last updated: 2023-12-07Bibliographically approved

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Uhlén, MathiasShoaie, SaeedPortlock, Theo John

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