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Regenerative Endodontics by Cell Homing: A Review of Recent Clinical trials
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Glycoscience. AIMES - Center for the Advancement of Integrated Medical and Engineering Sciences at KI Karolinska Institutet; Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Odontology, University of Oslo, 0317 Oslo, Norway.ORCID iD: 0000-0001-7257-5522
Department of Endodontics, Universidade Federal Fluminense, R. Mario Santos Braga, 30 - Centro, Niteroi - RJ, 24020-140, Brazil.
Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Odontology, University of Oslo, 0317 Oslo, Norway.
Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Odontology, University of Oslo, 0317 Oslo, Norway.
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2023 (English)In: Journal of Endodontics, ISSN 0099-2399, E-ISSN 1878-3554, Journal of Endodontics, ISSN 0099-2399, Vol. 49, no 1, p. 4-17Article, review/survey (Refereed) Published
Abstract [en]

Introduction: The conventional treatment for irreversibly inflamed or necrotic teeth is root canal treatment or apexification. Regenerative endodontics aims to regenerate the damaged “pulp-like” tissue, which can preserve the teeth' vitality and sensitivity while avoiding necrosis. The main clinical benefit is root maturation. The “pulp-like” tissue does not refer to regenerated pulp tissue with an odontoblastic layer or the formation of pulp-dentin complexes. The cell homing technique is built on endogenous stem cells and their capacity to regenerate tissue. Cell homing refers to endogenous cells’ migration or infiltration into the cite when stimulated by physiochemical or biological stimuli or by passive flow with a blood clot from the apical tissue. Its Regenerative Endodontic Procedures success criteria are defined by the American Association of Endodontists. The purpose of this article is to provide an overview of vital pulp tissue and various strategies to promote regeneration of damaged pulp tissue. The cell homing technique will be reviewed through clinical trials. Methods: We performed a comprehensive literature review on a total of nine clinical trials of regenerative endodontics using the cell-homing technique based on three databases and duplicate manuscripts were removed. Results: Regenerative endodontics using the cell-homing technique shows promising results that can be translated into clinical practice. However, a favorable result was observed in immature teeth, and the results are contradictory in mature teeth. Conclusion: Regeneration therapy is an attractive new alternative to conventional endodontic treatments. Preservation of vitality and continuation of root development in damaged teeth would be a clear advantage.

Place, publisher, year, edition, pages
Elsevier BV , 2023. Vol. 49, no 1, p. 4-17
Keywords [en]
Biomaterials, cell homing technique, growth factors, pulp tissues, regenerative endodontic, scaffolds, stem cells
National Category
Dentistry
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URN: urn:nbn:se:kth:diva-329104DOI: 10.1016/j.joen.2022.09.008ISI: 001016502200001PubMedID: 36270575Scopus ID: 2-s2.0-85143144945OAI: oai:DiVA.org:kth-329104DiVA, id: diva2:1768400
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QC 20230615

Available from: 2023-06-15 Created: 2023-06-15 Last updated: 2023-07-14Bibliographically approved

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Yan, Hongji

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