Interlayers in asphalt pavements are potential structural damage initiators. In order to better understand the quantitative role of interlayer parameters, such as surface roughness, binder type, binder content and loading type on interlayer shear strength, this paper focuses on the effects of particle interlock and contact conditions on interlayer strength through experimental and numerical modelling. Experimentally, interlayer shear box strength tests on a model material consisting of stiff binder blended with steel balls are performed with and without normal force confinement. A Discrete Element method model of the test is developed using measurements of the model material for calibrating the contact law and for validating the model. It is shown that this model captures adequately the measured force-displacement response of the specimens. It is thus a feasible starting point for numerically and experimentally studying the role of binder and tack coat regarding interlayer shear strength of real asphalt layers.