Integrated Computational Materials Engineering (ICME) has proved to be an efficient tool for understanding the process-structure-properties relationships and help us design materials. In the case of cemented carbides, ICME can be used to study how well-established relationships are affected by new industry challenges, like the replacement of Co by alternative binder materials. The C-window is one of the most critical parameters in cemented carbides and is defined as the range in C-content for which phases detrimental to the mechanical properties are avoided. For alternative binder materials, the processing window may become very narrow, and a good understanding of its limits becomes crucial. The low-C side of the C-window is limited by the precipitation of η-carbides (M6C/M12C). Here, a systematic and integrated study on the formation of η-carbides as a function of binder chemical composition, cooling rate and microstructure is presented.