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Fracture of porcine aorta-Part 1: symconCT fracture testing and DIC
KTH, School of Engineering Sciences (SCI), Engineering Mechanics, Vehicle Engineering and Solid Mechanics, Solid Mechanics.ORCID iD: 0000-0001-6544-628X
KTH, School of Engineering Sciences (SCI), Engineering Mechanics, Vehicle Engineering and Solid Mechanics, Solid Mechanics.
KI Karolinska Inst, Dept Mol Med & Surg, Solna, Sweden..
KTH, School of Engineering Sciences (SCI), Engineering Mechanics, Vehicle Engineering and Solid Mechanics, Solid Mechanics.
2023 (English)In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 167, p. 147-157Article in journal (Refereed) Published
Abstract [en]

Tissue failure and damage are inherent parts of vascular diseases and tightly linked to clinical events. Additionally, experimental set-ups designed to study classical engineering materials are suboptimal in the exploration of vessel wall fracture properties. The classical Compact Tension (CT) test was augmented to enable stable fracture propagation, resulting in the symmetry-constraint Compact Tension (symconCT) test, a suitable set-up for fracture testing of vascular tissue. The test was combined with Digital Image Correlation (DIC) to study tissue fracture in 45 porcine aorta specimens. Test specimens were loaded in axial and circumferential directions in a physiological solution at 37 & DEG;C. Loading the aortic vessel wall in the axial direction resulted in mode I tissue failure and a fracture path aligned with the circumferential vessel direction. Circumferential loading resulted in mode I-dominated failure with multiple deflections of the fracture path. The aorta ruptured at a principal Green-Lagrange strain of approximately 0.7, and strain rate peaks that develop ahead of the crack tip reached nearly 400 times the strain rate on average over the test specimen. It required approximately 70% more external work to fracture the aorta by circumferential than axial load; normalised with the fracture surface, similar energy levels are, however, observed. The symconCT test resulted in a stable fracture propagation, which, combined with DIC, provided a set-up for the in-depth analysis of vascular tissue failure. The high strain rates ahead of the crack tip indicate the significance of rate effects in the constitutive description of vascular tissue fracture.

Place, publisher, year, edition, pages
Elsevier BV , 2023. Vol. 167, p. 147-157
Keywords [en]
Soft biological tissue, Vascular tissue, Fracture, In-vitro experiment, Finite deformation
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:kth:diva-334693DOI: 10.1016/j.actbio.2023.06.022ISI: 001046729500001PubMedID: 37355178Scopus ID: 2-s2.0-85150649492OAI: oai:DiVA.org:kth-334693DiVA, id: diva2:1791036
Note

QC 20230824

Available from: 2023-08-24 Created: 2023-08-24 Last updated: 2023-08-24Bibliographically approved

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Alloisio, MartaChatziefraimidou, MarinaGasser, T. Christian

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