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Advance in oral delivery of living material
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, P. R. China, 197 Ruijin 2nd Road; Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China, 197 Ruijin 2nd Road.
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.ORCID iD: 0000-0001-7639-1173
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, P. R. China, 197 Ruijin 2nd Road.
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Fibre- and Polymer Technology, Coating Technology.ORCID iD: 0000-0002-9200-8004
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2023 (English)In: Biomedical Technology, E-ISSN 2949-723X, Vol. 3, p. 26-39Article, review/survey (Refereed) Published
Abstract [en]

Nowadays, living therapeutics is a promising candidate among various therapies, and oral administration of living therapeutics characterized by universality and safety avail to make the transition from bench to bedside. However, precise delivery and continuous maintenance of cell viability and activity to acquire stable and ideal therapeutic efficacy remain challenging. Living material is the smart integration of the flexibly programmable functionality of biomaterial and the autonomous environmental responsiveness of living elements, heralding a new era of biotherapeutics in addressing human health concerns. Here, our review aims at presenting an overview of the status of the oral delivery of living material from a biological, technical, and practical perspective, describing the clinical significance and potential, the current technological development and dilemma, as well as the prospect.

Place, publisher, year, edition, pages
Elsevier BV , 2023. Vol. 3, p. 26-39
Keywords [en]
Biomaterial, Gut microbiome, Living material, Oral administration
National Category
Dentistry Materials Engineering
Identifiers
URN: urn:nbn:se:kth:diva-338441DOI: 10.1016/j.bmt.2022.12.003Scopus ID: 2-s2.0-85149338749OAI: oai:DiVA.org:kth-338441DiVA, id: diva2:1812457
Note

QC 20231116

Available from: 2023-11-16 Created: 2023-11-16 Last updated: 2023-11-16Bibliographically approved

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Fan, YanmiaoMalkoch, Michael

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