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Novel tetrahydronaphthalen-1-yl-phenethyl ureas: synthesis and dual antibacterial-anticancer activities
Erzurum Tech Univ, Fac Sci, Dept Basic Sci, Erzurum, Turkiye..
Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, Erzurum, Turkiye.;St James Univ Hosp, Univ Leeds, Fac Med & Hlth, Leeds, England..
Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, Erzurum, Turkiye..
Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkiye..
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2024 (English)In: Journal of enzyme inhibition and medicinal chemistry (Print), ISSN 1475-6366, E-ISSN 1475-6374, Vol. 39, no 1, article id 2286925Article in journal (Refereed) Published
Abstract [en]

Cancer and antibiotic-resistant bacterial infections are significant global health challenges. The resistance developed in cancer treatments intensifies therapeutic difficulties. In addressing these challenges, this study synthesised a series of N,N '-dialkyl urea derivatives containing methoxy substituents on phenethylamines. Using isocyanate for the efficient synthesis yielded target products 14-18 in 73-76% returns. Subsequently, their antibacterial and anticancer potentials were assessed. Cytotoxicity tests on cancer cell lines, bacterial strains, and a healthy fibroblast line revealed promising outcomes. All derivatives demonstrated robust antibacterial activity, with MIC values ranging from 0.97 to 15.82 mu M. Notably, compounds 14 and 16 were particularly effective against the HeLa cell line, while compounds 14, 15, and 17 showed significant activity against the SH-SY5Y cell line. Importantly, these compounds had reduced toxicity to healthy fibroblast cells than to cancer cells, suggesting their potential as dual-functioning agents targeting both cancer and bacterial infections.

Place, publisher, year, edition, pages
Informa UK Limited , 2024. Vol. 39, no 1, article id 2286925
Keywords [en]
Antibacterial activity, anticancer activity, isocyanates, N, N'-dialkyl urea, phenethylamine
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:kth:diva-341544DOI: 10.1080/14756366.2023.2286925ISI: 001117761700001PubMedID: 38062550Scopus ID: 2-s2.0-85179904202OAI: oai:DiVA.org:kth-341544DiVA, id: diva2:1822234
Note

QC 20231222

Available from: 2023-12-22 Created: 2023-12-22 Last updated: 2024-01-02Bibliographically approved

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Mardinoglu, Adil

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