Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Flow-free transport of cells in microchannels by frequency-modulated ultrasound
KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. (Biomedical & X-Ray Physics)ORCID-id: 0000-0002-4720-2756
KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. (Cell Physics)
KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. (Cell Physics)ORCID-id: 0000-0001-5178-7593
KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. (Biomedical & X-Ray Physics)
2009 (Engelska)Ingår i: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 9, s. 833-837Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We demonstrate flow-free transport of cells and particles by the use of frequency-modulated ultrasonic actuation of a microfluidic chip. Two different modulation schemes are combined: A rapid (1 kHz) linear frequency sweep around similar to 6.9 MHz is used for two-dimensional spatial stabilization of the force field over a 5 mm long inlet channel of constant cross section, and a slow (0.2-0.7 Hz) linear frequency sweep around similar to 2.6 MHz is used for flow-free ultrasonic transport and positioning of cells or particles. The method is used for controlling the motion and position of cells monitored with high-resolution optical microscopy, but can also be used more generally for improving the robustness and performance of ultrasonic manipulation micro-devices.

Ort, förlag, år, upplaga, sidor
2009. Vol. 9, s. 833-837
Nyckelord [en]
manipulation; particles; chip; separation; channels
Nationell ämneskategori
Den kondenserade materiens fysik
Identifikatorer
URN: urn:nbn:se:kth:diva-10918DOI: 10.1039/B816675GISI: 000263847000012PubMedID: 19255666Scopus ID: 2-s2.0-61849133822OAI: oai:DiVA.org:kth-10918DiVA, id: diva2:231814
Anmärkning
QC 20100730Tillgänglig från: 2009-08-18 Skapad: 2009-08-18 Senast uppdaterad: 2020-03-09Bibliografiskt granskad
Ingår i avhandling
1. Multidimensional Ultrasonic Standing Wave Manipulation in Microfluidic Chips
Öppna denna publikation i ny flik eller fönster >>Multidimensional Ultrasonic Standing Wave Manipulation in Microfluidic Chips
2009 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The use of ultrasonic standing waves for contactless manipulation of microparticles in microfluidic systems is a field with potential to become a new standard tool in lab-on-chip systems. Compared to other contactless manipulation methods ultrasonic standing wave manipulation shows promises of gentle cell handling, low cost, and precise temperature control. The technology can be used both for batch handling, such as sorting and aggregation, and handling of single particles.

This doctoral Thesis presents multi-dimensional ultrasonic manipulation, i.e., manipulation in both two and three spatial dimensions as well as time-dependent manipulation of living cells and microbeads in microfluidic systems. The lab-on-chip structures used allow for high-quality optical microscopy, which is central to many bio-applications. It is demonstrated how the ultrasonic force fields can be spatially confined to predefined regions in the system, enabling sequential manipulation functions. Furthermore, it is shown how frequency-modulated signals can be used both for spatial stabilization of the force fields as well as for flow-free transport of particles in a microchannel. Design parameters of the chip-transducer systems employed are investigated experimentally as well as by numerical simulations. It is shown that three-dimensional resonances in the solid structure of the chip strongly influences the resonance shaping in the channel.

Ort, förlag, år, upplaga, sidor
Stockholm: KTH, 2009. s. ix, 83
Serie
Trita-FYS, ISSN 0280-316X ; 2009:44
Nationell ämneskategori
Den kondenserade materiens fysik
Identifikatorer
urn:nbn:se:kth:diva-10919 (URN)978-91-7415-398-9 (ISBN)
Disputation
2009-09-11, FD5, Roslagstullsbacken 21, Stockholm, 14:00 (Engelska)
Opponent
Handledare
Anmärkning
QC 20100730Tillgänglig från: 2009-09-01 Skapad: 2009-08-18 Senast uppdaterad: 2010-07-30Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopushttp://www.rsc.org/publishing/journals/LC/article.asp?doi=b816675g

Personposter BETA

Manneberg, OttoÖnfelt, Björn

Sök vidare i DiVA

Av författaren/redaktören
Manneberg, OttoVanherberghen, BrunoÖnfelt, BjörnWiklund, Martin
Av organisationen
Tillämpad fysik
I samma tidskrift
Lab on a Chip
Den kondenserade materiens fysik

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 144 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf