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Reflectometry, ablation and fluid retrieval with an optical fiber
KTH, Skolan för informations- och kommunikationsteknik (ICT), Fotonik och optik, Kvantelektronik och -optik, QEO.
KTH, Skolan för informations- och kommunikationsteknik (ICT), Fotonik och optik, Kvantelektronik och -optik, QEO.ORCID-id: 0000-0002-2082-9583
KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Laserfysik.
2010 (engelsk)Inngår i: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 18, nr 1, s. 134-140Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A technique combining low-coherence reflectometry, laser ablation and microfluidics in a single microstructured fiber is developed. Experimental results demonstrate the possibility to ablate thin aluminum foil samples with fiber-guided Nd:YAG laser light, to collect liquid in the holes of the fiber and to simultaneously monitor the positioning of fiber for ablation and the fluid collection process with low-coherence reflectometry. Potential applications of the technique include minimally invasive retrieval of liquid samples with low contamination risk.

sted, utgiver, år, opplag, sider
2010. Vol. 18, nr 1, s. 134-140
Emneord [en]
coherence tomography, tissue ablation, laser-ablation
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-19099DOI: 10.1364/OE.18.000134ISI: 000273249400018Scopus ID: 2-s2.0-73549094703OAI: oai:DiVA.org:kth-19099DiVA, id: diva2:337146
Forskningsfinansiär
Swedish Research Council
Merknad
QC 20100525Tilgjengelig fra: 2010-08-05 Laget: 2010-08-05 Sist oppdatert: 2017-12-12bibliografisk kontrollert
Inngår i avhandling
1. Increased Functionality of Optical Fibers for Life-Science Applications
Åpne denne publikasjonen i ny fane eller vindu >>Increased Functionality of Optical Fibers for Life-Science Applications
2014 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

The objective of this thesis work is to increase the functionality of optical fibers for possible applications in life-sciences. Optical fibers are a promising technology for use in biology and medicine. They are low-costwaveguides, flexible and have a small cross-section. They can guide high-power light with low loss in a micrometer core-size. These features make fibers attractive for minimally-invasive,in-vivostudies. The backwards guidance of the optical signal allows for real-time monitoring of the distance to the scattering targets and to study the environment through Raman scattering and fluorescence excitation. The longitudinal holes introduced in the fibers can be used,for instance,for delivery of medicine to a specific regionof a body. They could even be used for the extractionof species considered interesting for further analysis, for example, studyingcells that may be cancer-related.

This thesis deals with four main topics. First, a demonstration is presented of the combination of high-power light guidance for ablation, low-power light reflectometry for positioning, and for liquid retrieval in a single fiber. It was found that in order to exploit the microfluidic possibilities available in optical fibers with holes, one needs to be able to combine fluids and light in a fiber without hindering the low-loss light guidance and the fluid flow. Secondly, one should also be able to couple light into the liquids and backout again. This is the subject of another paper in the present thesis. It was also observed that laser excitation through a fiber for the collection of a low-intensity fluorescence signal was often affected by the luminescence noise createdby the primary-coating of the fiber. This problem makes it difficult to measure low light-levels, for example, from single-cells. Athirdpaper in this thesis then describes a novel approach to reduce the luminescence from the polymer coating of the fiber, with the use of a nanometer-thick carbon layer on the cladding surface. Finally, exploiting some of the results described earlier, an optical fiber with longitudinal holes is used for the excitation, identification and for the collection of particles considered being of interest. The excitation light is guided in the fiber, the identification is performed by choosing the fluorescent particles with the appropriate wavelength, and, when a particle of interest is sufficiently near the fiber-tip, the suction system is activated for collection of the particle with good specificity.

It is believed that the work described in this thesis could open the doors for applications in life-sciences and the future use of optical fibers for in-vivo studies.

sted, utgiver, år, opplag, sider
Stockholm: KTH Royal Institute of Technology, 2014. s. xii, 63
Serie
TRITA-FYS, ISSN 0280-316X ; 2014:15
Emneord
Fiberoptics, microstructured fiber, fiber - based optofluidics, laser ablation, microfluidics, reflectometry, fluorescence detection, fiber - based spectroscopy
HSV kategori
Forskningsprogram
Fysik
Identifikatorer
urn:nbn:se:kth:diva-145319 (URN)978-91-7595-122-5 (ISBN)
Disputas
2014-05-21, sal FB5, AlbaNova Universitetscentrum, Roslagstullsbacken 21, Stockholm, 10:00 (engelsk)
Opponent
Veileder
Merknad

QC 20140516

Tilgjengelig fra: 2014-05-16 Laget: 2014-05-15 Sist oppdatert: 2014-05-16bibliografisk kontrollert

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