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PET Studies of D2-Receptor Binding in Striatal and Extrastriatal Brain Regions: Biochemical Support In Vivo for Separate Dopaminergic Systems in Humans
KTH, Skolan för datavetenskap och kommunikation (CSC), Beräkningsbiologi, CB.ORCID-id: 0000-0003-0281-9450
Vise andre og tillknytning
2010 (engelsk)Inngår i: Synapse, ISSN 0887-4476, E-ISSN 1098-2396, Vol. 64, nr 6, s. 478-485Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Most molecular imaging studies of the dopamine (DA) system performed to date have focused on the striatum, a region receiving dense dopaminergic innervation. In clinical research on the DA D2-receptor, striatal binding has often been regarded as an index of global DA function, based on the underlying assumption of common regulatory mechanisms for receptor expression across brain regions. Recent data has challenged this view, suggesting differences in genetic regulation between striatal and extrastriatal brain regions. The relationship between binding levels in brain regions has, however, not been directly examined in the same sample. In this study, we searched for interregional correlations between DA D2-receptor availability as determined with Positron Emission Tomography in 16 control subjects. The radioligands [C-11]raclopride and [C-11]FLB 457 were used for measurements of D2-receptor binding in striatal and extrastriatal regions, respectively. No correlation was observed between D2-receptor availability in striatum and any of the extrastriatal regions, as assessed using both region of interest- and voxel-based analyses. Instead, the pattern of correlations was consistent with the model of separate dopaminergic systems as has been originally observed in rodents. These preliminary results encourage approaches searching for individual patterns of receptor binding across the whole brain volume in clinical studies on the dopamine system.

sted, utgiver, år, opplag, sider
2010. Vol. 64, nr 6, s. 478-485
Emneord [en]
PET, human, brain, neurotransmission
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-19403DOI: 10.1002/syn.20765ISI: 000276938200009PubMedID: 20175222Scopus ID: 2-s2.0-77952918281OAI: oai:DiVA.org:kth-19403DiVA, id: diva2:337450
Forskningsfinansiär
Swedish Research Council, VR 09114
Merknad
QC 20100525 QC 20111227Tilgjengelig fra: 2010-08-05 Laget: 2010-08-05 Sist oppdatert: 2018-01-12bibliografisk kontrollert

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