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Liquid Crystalline Polymer Pouches for Local Anaesthetic Emulsion
KTH, Tidigare Institutioner                               , Polymerteknologi.
KTH, Tidigare Institutioner                               , Polymerteknologi.
2001 (engelsk)Inngår i: Packaging technology & science, ISSN 0894-3214, E-ISSN 1099-1522, Vol. 14, nr 4, s. 159-170Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In order to enhance the long-term properties of a high-pH local anaesthetic drug, emulsion tests were conducted where the emulsion was stored in pouches made of a compression moulded high-barrier liquid-crystalline polymer, Vectra A950. The oxygen permeability of the pouch materia I was too low to be detected at 23 degreesC and 0% relative humidity with the instrument used. The water vapour transmission rate was 0.135 (g.mm/m(2).day) at 38 degreesC and 100% relative humidity. The emulsion, containing prilocain and lidocain as active substances, was stored in pouches which were sealed by the thermal impulse technique at 260 degreesC for 1.08 s. It was possible to obtain good quality films and good quality seals by optimization of the compression moulding and sealing operations. The concentrations of prilocain and lidocain in the emulsion were studied for 14 weeks at two different temperatures, 40 degreesC and 60 degreesC, and at 100% relative humidity. The decrease in concentration was higher for prilocain (5.4-8.3%) than for lidocain (3.4-3.6%). The loss of the substances from the emulsion was due mainly to adsorption onto the polar surface of the liquid crystalline polymer.

sted, utgiver, år, opplag, sider
2001. Vol. 14, nr 4, s. 159-170
Emneord [en]
liquid crystalline polymer, compression-moulding, pouches, local anaesthetic, prilocain, lidocain, polyethylene
Identifikatorer
URN: urn:nbn:se:kth:diva-21075ISI: 000171965400005OAI: oai:DiVA.org:kth-21075DiVA, id: diva2:339772
Merknad
QC 20100525Tilgjengelig fra: 2010-08-10 Laget: 2010-08-10 Sist oppdatert: 2017-12-12bibliografisk kontrollert

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