kth.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Stability puzzles in phage lambda
2002 (Engelska)Ingår i: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics: Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, ISSN 1063-651X, E-ISSN 1095-3787, Vol. 65, nr 5Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

In the absence of RecA-mediated cleavage of the repressor, the X prophage is exceptionally stable. We. develop a stochastic model that predicts the stability of such epigenetic states from affinities of the molecular components. We find that the stability, in particular, depends on the maximum possible cI protein production. and on the number of translated cro proteins per transcribed mRNA. We apply the model to the behavior of recently published mutants of O-R and find, in particular, that a mutant that overexpress cro behaves in a different way than what was predicted, thus suggesting that the current view of the O-R switch is incomplete. The approach described here should be generally applicable to the stability of expressed states.

Ort, förlag, år, upplaga, sidor
2002. Vol. 65, nr 5
Nyckelord [en]
escherichia-coli, bacteriophage-lambda, gene-regulation, transcription initiation, translation initiation, operator binding, cro repressor, prm promoter, dna, switch
Identifikatorer
URN: urn:nbn:se:kth:diva-21672DOI: 10.1103/PhysRevE.65.051914ISI: 000176552300091PubMedID: 12059600OAI: oai:DiVA.org:kth-21672DiVA, id: diva2:340370
Anmärkning
QC 20100525Tillgänglig från: 2010-08-10 Skapad: 2010-08-10 Senast uppdaterad: 2022-09-13Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Sök vidare i DiVA

Av författaren/redaktören
Aurell, Erik
I samma tidskrift
Physical Review E. Statistical, Nonlinear, and Soft Matter Physics: Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 41 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf