Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Agglomeration of paracetamol during crystallization in pure and mixed solvents
KTH, Tidigare Institutioner, Kemiteknik.
KTH, Tidigare Institutioner, Kemiteknik.
KTH, Tidigare Institutioner, Kemiteknik.
2004 (Engelska)Ingår i: Industrial & Engineering Chemistry Research, ISSN 0888-5885, E-ISSN 1520-5045, Vol. 43, nr 2, s. 629-637Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The agglomeration of paracetamol during crystallization has been investigated. It is shown that the agglomeration behavior depends on the solvent composition. The following solvent systems were used in isothermal desupersaturation experiments: five different acetone-toluene-water mixtures and the pure solvents acetone, 2-propanol, acetic acid, and ethylene glycol. Sieving, image analysis processed by principal component analysis, and agglomerate strength measurements were used to characterize the product particles. Mixtures with a high concentration of acetone were found to produce a highly agglomerated product with strong agglomerates. In contrast, products from crystallization in ethylene glycol, 2-propanol, acetic acid, and acetone-toluene-water mixtures having a high concentration of water contained not only agglomerates but also a significant fraction of single crystals. Furthermore, the agglomerates formed in these solvents were much weaker than those produced in mixtures with a high content of acetone. The results were correlated with the polarity and the viscosity of the solvents.

Ort, förlag, år, upplaga, sidor
2004. Vol. 43, nr 2, s. 629-637
Nyckelord [en]
strength measurement, precipitation, crystals, mixtures
Nationell ämneskategori
Kemiteknik
Identifikatorer
URN: urn:nbn:se:kth:diva-23098DOI: 10.1021/ie0301280ISI: 000188227200039Scopus ID: 2-s2.0-0346496605OAI: oai:DiVA.org:kth-23098DiVA, id: diva2:341796
Anmärkning
QC 20100525 QC 20111031Tillgänglig från: 2010-08-10 Skapad: 2010-08-10 Senast uppdaterad: 2017-12-12Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextScopus

Sök vidare i DiVA

Av författaren/redaktören
Ålander, Eva M.Uusi-Penttila, Marketta S.Rasmuson, Åke C.
Av organisationen
Kemiteknik
I samma tidskrift
Industrial & Engineering Chemistry Research
Kemiteknik

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 122 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf