Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Dynamic combinatorial carbohydrate libraries: Probing the binding site of the concanavalin A lectin
KTH, Tidigare Institutioner, Kemi.ORCID-id: 0000-0002-1533-6514
2004 (Engelska)Ingår i: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 10, nr 7, s. 1711-1715Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Dynamic combinatorial chemistry (DCC) has emerged as an efficient approach to receptor/ligand identification based on the generation of combinatorial libraries by reversible interconversion of the library constituents. In this study, the implementation of such libraries on carbohydrate-lectin interactions was examined with the plant lectin Concanavalin A as a target species. Dynamic carbohydrate libraries were generated from a pool of carbohydrate aldehydes and hydrazide linker/scaffold components through re- versible acylhydrazone exchange, resulting in libraries containing up to 474 constituents. Dynamic deconvolution allowed the efficient identification of the structural features required for binding to Concanavalin A and the selection of a strong binder, a tritopic mannoside, showing an IC50-value of 22 mum.

Ort, förlag, år, upplaga, sidor
2004. Vol. 10, nr 7, s. 1711-1715
Nyckelord [en]
carbohydrates, combinatorial chemistry, concanavalin A, glycoconjugates, receptors, galnac-specific lectins, molecular recognition, chemical evolution, generation, amplification, inhibitors, chemistry, helicate, dendrimers, component
Nationell ämneskategori
Kemi
Identifikatorer
URN: urn:nbn:se:kth:diva-23323DOI: 10.1002/chem.200305551ISI: 000220771700014Scopus ID: 2-s2.0-1842784768OAI: oai:DiVA.org:kth-23323DiVA, id: diva2:342021
Anmärkning
QC 20100525Tillgänglig från: 2010-08-10 Skapad: 2010-08-10 Senast uppdaterad: 2019-12-20Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextScopus

Sök vidare i DiVA

Av författaren/redaktören
Ramström, Olof
Av organisationen
Kemi
I samma tidskrift
Chemistry - A European Journal
Kemi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 64 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf