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Does indomethacin for closure of patent ductus arteriosus affect cerebral function?
Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital-Östra.
Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital-Östra.
School of Engineering, University of Borås.
Neoventa Medical AB, Göteborg.
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2010 (Engelska)Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 99, nr 10, s. 1493-1497Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: To study whether indomethacin used in conventional dose for closure of patent ductus arteriosus affects cerebral function measured by Electroencephalograms (EEG) evaluated by quantitative measures. Study design: Seven premature neonates with haemodynamically significant persistent ductus arteriosus were recruited. EEG were recorded before, during and after an intravenous infusion of 0.2 mg/kg indomethacin over 10 min. The EEG was analysed by two methods with different degrees of complexity for the amount of low-activity periods (LAP, "suppressions") as an indicator of affection of cerebral function. Results: Neither of the two methods identified any change in the amount of LAPs in the EEG as compared to before the indomethacin infusion. Conclusion: Indomethacin in conventional dose for closure of patent ductus arteriosus does not affect cerebral function as evaluated by quantitative EEG.

Ort, förlag, år, upplaga, sidor
2010. Vol. 99, nr 10, s. 1493-1497
Nyckelord [en]
BIRTH-WEIGHT INFANTS, PRETERM INFANTS, INTRAVENTRICULAR HEMORRHAGE, PREMATURE-INFANTS, HEMODYNAMICS, TRIAL, OXYGENATION, PREVENTION, IBUPROFEN, PROPHYLAXIS
Nationell ämneskategori
Medicin och hälsovetenskap Pediatrik
Identifikatorer
URN: urn:nbn:se:kth:diva-26714DOI: 10.1111/j.1651-2227.2010.01857.xISI: 000281556700016Scopus ID: 2-s2.0-77956357318OAI: oai:DiVA.org:kth-26714DiVA, id: diva2:372670
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QC 20150727

Tillgänglig från: 2010-11-26 Skapad: 2010-11-26 Senast uppdaterad: 2017-12-12Bibliografiskt granskad

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Lindecrantz, Kaj
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Medicinska sensorer, signaler och system (MSSS) (Stängd 20130701)
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