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Replication-biased genome organisation in the crenarchaeon Sulfolobus
KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för bioteknologi (BIO), Genteknologi.ORCID-id: 0000-0002-3627-6899
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2010 (engelsk)Inngår i: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 11, s. 454-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Species of the crenarchaeon Sulfolobus harbour three replication origins in their single circular chromosome that are synchronously initiated during replication. Results: We demonstrate that global gene expression in two Sulfolobus species is highly biased, such that early replicating genome regions are more highly expressed at all three origins. The bias by far exceeds what would be anticipated by gene dosage effects alone. In addition, early replicating regions are denser in archaeal core genes (enriched in essential functions), display lower intergenic distances, and are devoid of mobile genetic elements. Conclusion: The strong replication-biased structuring of the Sulfolobus chromosome implies that the multiple replication origins serve purposes other than simply shortening the time required for replication. The higher-level chromosomal organisation could be of importance for minimizing the impact of DNA damage, and may also be linked to transcriptional regulation.

sted, utgiver, år, opplag, sider
2010. Vol. 11, s. 454-
Emneord [en]
CELL-CYCLE CHARACTERISTICS, ARCHAEON SULFOLOBUS, GENE-EXPRESSION, THERMOPHILIC ARCHAEA, CHROMATIN PROTEIN, ESCHERICHIA-COLI, SOLFATARICUS, BACTERIA, TRANSCRIPTION, EUKARYOTES
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Identifikatorer
URN: urn:nbn:se:kth:diva-26619DOI: 10.1186/1471-2164-11-454ISI: 000282787800003Scopus ID: 2-s2.0-77955494347OAI: oai:DiVA.org:kth-26619DiVA, id: diva2:374727
Merknad
QC 20101206Tilgjengelig fra: 2010-12-06 Laget: 2010-11-26 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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