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Fluorescence-surface enhanced Raman scattering co-functionalized gold nanorods as near-infrared probes for purely optical in vivo imaging
KTH, Skolan för informations- och kommunikationsteknik (ICT), Centra, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, Skolan för informations- och kommunikationsteknik (ICT), Centra, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, Skolan för informations- och kommunikationsteknik (ICT), Centra, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
KTH, Skolan för informations- och kommunikationsteknik (ICT), Centra, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
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2011 (Engelska)Ingår i: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 32, nr 6, s. 1601-1610Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Gold nanorods (GNRs) have been widely used for bio-imaging. However, GNRs assisted optical in vivo deep tissue imaging is severely restricted due to signal attenuation, low contrast, complex process or low real-timing. To overcome these problems, we functionalized GNRs with both near-infrared (NIR) fluorescence and surface enhanced Raman scattering (SERS) and utilized these co-functionalized GNRs for purely optical in vivo imaging of live mice. Our proposed technology has the combined advantages of high real-timing, high imaging contrast and deep detection ability. The distribution and excretion of intravenously injected GNRs in deep tissues of live mice were observed in vivo for the first time through purely optical imaging. We also demonstrated successfully in vivo biomedical applications of the co-functionalized GNRs to sentinel lymph node (SLN) mapping and tumor targeting of mice. The present technology has great future potentials for disease diagnosis and clinical therapies.

Ort, förlag, år, upplaga, sidor
2011. Vol. 32, nr 6, s. 1601-1610
Nyckelord [en]
Gold nanorods, Near-infrared, Fluorescence, Surface enhanced Raman scattering, Purely optical, In vivo imaging
Nationell ämneskategori
Teknik och teknologier
Identifikatorer
URN: urn:nbn:se:kth:diva-31364DOI: 10.1016/j.biomaterials.2010.10.058ISI: 000286698100016Scopus ID: 2-s2.0-78650300118OAI: oai:DiVA.org:kth-31364DiVA, id: diva2:404313
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QC 20110316

Tillgänglig från: 2011-03-16 Skapad: 2011-03-14 Senast uppdaterad: 2017-12-11Bibliografiskt granskad

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He, Sailing

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Qian, JunJiang, LiCai, FuhongWang, DanHe, Sailing
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Zhejiang-KTH Joint Research Center of Photonics, JORCEPElektroteknisk teori och konstruktion
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