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The chemistry of peroxynitrite: Implications for biological activity
KTH, Skolan för kemivetenskap (CHE), Kemi.
2008 (engelsk)Inngår i: Methods in Enzymology / [ed] Poole, RK, 2008, Vol. 436, s. 49-61Kapittel i bok, del av antologi (Fagfellevurdert)
Abstract [en]

In biological systems, nitric oxide (NO) combines rapidly with superoxide (O(2)(-)) to form peroxynitrite ion (ONOO(-)), a substance that has been implicated as a culprit in many diseases. Peroxynitrite ion is essentially stable, but its protonated form (ONOOH, pK(a) = 6.5 to 6.8) decomposes rapidly via homolysis of the O-O bond to form about 28% free NO(2) and OH radicals. At physiological pH and in the presence of large amounts of bicarbonate, ONOO- reacts with CO(2) to produce about 33% NO(2) and carbonate ion radicals (CO(3)(-)) in the bulk of the solution. The quantitative role of OH/CO(3)(-) and NO(2) radicals during the decomposition of peroxynitrite (ONOOH/ONOO(-)) under physiological conditions is described in detail. Specifically, the effect of the peroxynitrite dosage rate on the yield and distribution of the final products is demonstrated. By way of an example, the detailed mechanism of nitration of tyrosine, a vital aromatic amino acid, is delineated, showing the difference in the nitration yield between the addition of authentic peroxynitrite and its continuous generation by NO and O(2)(-) radicals.

sted, utgiver, år, opplag, sider
2008. Vol. 436, s. 49-61
Serie
Methods in Enzymology, ISSN 0076-6879 ; 436
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-47049DOI: 10.1016/S0076-6879(08)36004-2ISI: 000253294600004Scopus ID: 2-s2.0-42949134909ISBN: 978-0-12-374277-3 (tryckt)OAI: oai:DiVA.org:kth-47049DiVA, id: diva2:454539
Merknad
QC 20111107 UT WOS:000253294600004 Tilgjengelig fra: 2011-11-07 Laget: 2011-11-07 Sist oppdatert: 2011-11-07bibliografisk kontrollert

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