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Polypeptides having binding affinity for HER2
KTH, Skolan för bioteknologi (BIO), Molekylär Bioteknologi.ORCID-id: 0000-0002-9282-0174
Vise andre og tillknytning
2003 (engelsk)Patent (Annet (populærvitenskap, debatt, mm))
Abstract [en]

A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.

sted, utgiver, år, opplag, sider
2003.
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-51325OAI: oai:DiVA.org:kth-51325DiVA, id: diva2:463865
Patent
EP 1641818 (2008-12-03)
Merknad

AU 2004253835-B2 (2009-01-29); US 7993650 (2011-08-09); CN 1816563 (2011-02-09); JP 4871126-B2 (2012-02-08)

Tilgjengelig fra: 2011-12-12 Laget: 2011-12-12 Sist oppdatert: 2013-08-07bibliografisk kontrollert

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