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The cardiac effects of intracoronary angiotensin II infusion
Umeå Universitet.ORCID-id: 0000-0002-8987-9909
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2002 (Engelska)Ingår i: Anesthesia and Analgesia, ISSN 0003-2999, E-ISSN 1526-7598, Vol. 94, nr 4, s. 787-793Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Angiotensin II (Ang II) is a potent vasoconstrictor, which recently has been shown to also have significant inotropic effects. Previous results regarding the mechanisms of the acute inotropic effects of Ang II are not conclusive. We designed this study to investigate the local cardiac effects of intracoronary Ang II infusion in doses not affecting systemic circulation. Ang II (2.5-40 microg/h) was infused in the left coronary artery of Yorkshire pigs (n = 9) reaching calculated intracoronary Ang II concentrations of 842 +/- 310, 3342 +/- 1238, and 12448 +/- 4393 pg/mL, respectively. Cardiac systolic and diastolic function was evaluated by analysis of the left ventricular pressure-volume relationship. Coronary flow was measured by using a coronary sinus catheter and the retrograde thermodilution technique. No significant changes were seen in the systolic and diastolic function variables of heart rate, end-systolic elastance, preload recruitable stroke work, the time constant for isovolumetric relaxation, or in coronary vascular resistance and flow. The positive inotropic and chronotropic effects of Ang II seen in previous studies seem thus to be mediated via extracardiac actions of Ang II. Coronary vascular tone is not affected by local Ang II infusion in anesthetized pigs. IMPLICATIONS: The positive inotropic and chronotropic effects of angiotension II (Ang II) seen in previous studies seem to be mediated via extracardiac actions of Ang II. Coronary vascular tone is not affected by local Ang II infusion in anesthetized pigs.

Ort, förlag, år, upplaga, sidor
2002. Vol. 94, nr 4, s. 787-793
Nyckelord [en]
Angiotensin II/administration & dosage/*pharmacology, Animals, Coronary Circulation/drug effects, Coronary Vessels, Diastole/drug effects, Female, Heart/*drug effects, Hemodynamics/drug effects, Infusions, Intra-Arterial, Myocardial Contraction/drug effects, Stroke Volume/drug effects, Swine, Systole/drug effects, Thermodilution, Vascular Resistance/drug effects, Vasoconstrictor Agents/administration & dosage/*pharmacology, Ventricular Function, Left/drug effects
Nationell ämneskategori
Anestesi och intensivvård
Identifikatorer
URN: urn:nbn:se:kth:diva-58867DOI: 10.1097/00000539-200204000-00004ISI: 000174528600004PubMedID: 11916774Scopus ID: 2-s2.0-0036201460OAI: oai:DiVA.org:kth-58867DiVA, id: diva2:474813
Anmärkning

Broome, Michael Haney, M Osterlund, B Haggmark, S Johansson, G Biber, B Research Support, Non-U.S. Gov't United States Anesthesia and analgesia Anesth Analg. 2002 Apr;94(4):787-93, table of contents. NR 20140805

Tillgänglig från: 2012-01-10 Skapad: 2012-01-09 Senast uppdaterad: 2022-06-24Bibliografiskt granskad

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