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Oxadiazole isomers: all bioisosteres are not created equal
Vise andre og tillknytning
2012 (engelsk)Inngår i: MedChemComm, ISSN 2040-2503, E-ISSN 2040-2511, Vol. 3, nr 5, s. 600-604Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

sted, utgiver, år, opplag, sider
2012. Vol. 3, nr 5, s. 600-604
Emneord [en]
article, drug half life, drug protein binding, drug solubility, drug stability, drug structure, drug synthesis, human, hydrogen bond, isomer, lipophilicity, mouse, nonhuman, plasma protein binding, priority journal, rat, structure analysis, substitution reaction
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Identifikatorer
URN: urn:nbn:se:kth:diva-98021DOI: 10.1039/c2md20054fISI: 000304387300010Scopus ID: 2-s2.0-84860429692OAI: oai:DiVA.org:kth-98021DiVA, id: diva2:535006
Merknad
QC 20120619Tilgjengelig fra: 2012-06-19 Laget: 2012-06-18 Sist oppdatert: 2017-12-07bibliografisk kontrollert

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