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Software tool for analysis of breathing-related errors in transthoracic electrical bioimpedance spectroscopy measurements
KTH, Skolan för teknik och hälsa (STH), Patientsäkerhet (Stängd 20130701).ORCID-id: 0000-0001-7807-8682
KTH, Skolan för teknik och hälsa (STH).
KTH, Skolan för teknik och hälsa (STH), Medicinska sensorer, signaler och system (MSSS) (Stängd 20130701).
KTH, Skolan för teknik och hälsa (STH), Medicinska sensorer, signaler och system (MSSS) (Stängd 20130701).ORCID-id: 0000-0002-6995-967X
2012 (Engelska)Ingår i: Journal of Physics, Conference Series, ISSN 1742-6588, E-ISSN 1742-6596, Vol. 407, nr 1, s. 012028-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

During the last decades, Electrical Bioimpedance Spectroscopy (EBIS) has been applied in a range of different applications and mainly using the frequency sweep-technique. Traditionally the tissue under study is considered to be timeinvariant and dynamic changes of tissue activity are ignored and instead treated as a noise source. This assumption has not been adequately tested and could have a negative impact and limit the accuracy for impedance monitoring systems. In order to successfully use frequency-sweeping EBIS for monitoring time-variant systems, it is paramount to study the effect of frequency-sweep delay on Cole Model-based analysis. In this work, we present a software tool that can be used to simulate the influence of respiration activity in frequency-sweep EBIS measurements of the human thorax and analyse the effects of the different error sources. Preliminary results indicate that the deviation on the EBIS measurement might be significant at any frequency, and especially in the impedance plane. Therefore the impact on Cole-model analysis might be different depending on method applied for Cole parameter estimation.

Ort, förlag, år, upplaga, sidor
2012. Vol. 407, nr 1, s. 012028-
Nyckelord [en]
electrical bioimpedance spectroscopy, EBIS artefacts, frequency-sweep EBIS, Transthoracic Measurements, frequency-sweep spectroscopy of time-variant systems
Nationell ämneskategori
Annan medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:kth:diva-118870DOI: 10.1088/1742-6596/407/1/012028ISI: 000314985000028Scopus ID: 2-s2.0-84874095138OAI: oai:DiVA.org:kth-118870DiVA, id: diva2:609041
Konferens
1st Latin-American Conference on Bioimpedance, CLABIO 2012, 6 November 2012 through 9 November 2012, Joinville
Anmärkning

QC 20130304

Tillgänglig från: 2013-03-04 Skapad: 2013-03-04 Senast uppdaterad: 2017-12-06Bibliografiskt granskad
Ingår i avhandling
1. Aspects of Electrical Bioimpedance Spectrum Estimation
Öppna denna publikation i ny flik eller fönster >>Aspects of Electrical Bioimpedance Spectrum Estimation
2014 (Engelska)Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Electrical bioimpedance spectroscopy (EBIS) has been used to assess the status or composition of various types of tissue, and examples of EBIS include body composition analysis (BCA) and tissue characterisation for skin cancer detection. EBIS is a non-invasive method that has the potential to provide a large amount of information for diagnosis or monitoring purposes, such as the monitoring of pulmonary oedema, i.e., fluid accumulation in the lungs. However, in many cases, systems based on EBIS have not become generally accepted in clinical practice. Possible reasons behind the low acceptance of EBIS could involve inaccurate models; artefacts, such as those from movements; measurement errors; and estimation errors. Previous thoracic EBIS measurements aimed at pulmonary oedema have shown some uncertainties in their results, making it difficult to produce trustworthy monitoring methods. The current research hypothesis was that these uncertainties mostly originate from estimation errors. In particular, time-varying behaviours of the thorax, e.g., respiratory and cardiac activity, can cause estimation errors, which make it tricky to detect the slowly varying behaviour of this system, i.e., pulmonary oedema.

The aim of this thesis is to investigate potential sources of estimation error in transthoracic impedance spectroscopy (TIS) for pulmonary oedema detection and to propose methods to prevent or compensate for these errors.   This work is mainly focused on two aspects of impedance spectrum estimation: first, the problems associated with the delay between estimations of spectrum samples in the frequency-sweep technique and second, the influence of undersampling (a result of impedance estimation times) when estimating an EBIS spectrum. The delay between frequency sweeps can produce huge errors when analysing EBIS spectra, but its effect decreases with averaging or low-pass filtering, which is a common and simple method for monitoring the time-invariant behaviour of a system. The results show the importance of the undersampling effect as the main estimation error that can cause uncertainty in TIS measurements.  The best time for dealing with this error is during the design process, when the system can be designed to avoid this error or with the possibility to compensate for the error during analysis. A case study of monitoring pulmonary oedema is used to assess the effect of these two estimation errors. However, the results can be generalised to any case for identifying the slowly varying behaviour of physiological systems that also display higher frequency variations.  Finally, some suggestions for designing an EBIS measurement system and analysis methods to avoid or compensate for these estimation errors are discussed.

Ort, förlag, år, upplaga, sidor
Stockholm: KTH Royal Institute of Technology, 2014. s. xi, 36
Serie
TRITA-STH : report, ISSN 1653-3836 ; 2014:4
Nyckelord
Electrical Bioimpedance Spectroscopy, Thoracic Bioimpedance Spectroscopy, Sub-Nyquist Sampling, Undersampling, Aliasing in Electrical Bioimpedance, Bioimpedance Estimation Error.
Nationell ämneskategori
Medicinteknik Signalbehandling
Forskningsämne
Medicinsk teknologi; Elektro- och systemteknik
Identifikatorer
urn:nbn:se:kth:diva-145643 (URN)978-91-7595-196-6 (ISBN)
Presentation
2014-08-21, 221, Alfred Nobels Allé 10, Flemingsberg, 15:37 (Engelska)
Opponent
Handledare
Anmärkning

QC 20140604

Tillgänglig från: 2014-06-04 Skapad: 2014-05-23 Senast uppdaterad: 2014-06-04Bibliografiskt granskad

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Patientsäkerhet (Stängd 20130701)Skolan för teknik och hälsa (STH)Medicinska sensorer, signaler och system (MSSS) (Stängd 20130701)
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