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Benefit of Adaptive Optics Aberration Correction at Preferred Retinal Locus
KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Biomedicinsk fysik och röntgenfysik.
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2012 (Engelska)Ingår i: Optometry and Vision Science, ISSN 1040-5488, E-ISSN 1538-9235, Vol. 89, nr 9Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose: To investigate the effect of eccentric refractive correction and full aberration correction on both high and low contrast grating resolution at the preferred retinal locus (PRL) of a single low vision subject with a longstanding central scotoma.

Methods: The subject was a 68 year-old female with bilateral absolute central scotoma due to Stargardt’s disease. She has developed a single PRL located 25° nasally of the damaged macula in her left eye, this being the better of the two eyes. High- (100%) and low contrast (25% & 10%) grating resolution acuity was evaluated using four different correction conditions. The first two corrections were solely refractive error corrections; namely habitual spectacle correction and full sphero-cylindrical correction. The latter two corrections were two versions of adaptive optics corrections of all aberrations; namely full sphero-cylindrical refractive correction with additional aberration correction and habitual spectacle correction with aberration correction.

Results: The mean high contrast (100%) resolution acuity with her habitual correction was 1.06 logMAR, which improved to 1.00 logMAR with full sphero-cylindrical correction. Under the same conditions, low contrast (25%) acuity improved from 1.30 logMAR to 1.14 logMAR. With adaptive optics aberration correction, the high contrast resolution acuities improved to 0.92/0.89 logMAR and the low contrast acuities, to 1.06/1.04 logMAR under both correction modalities. The low contrast (10%) resolution acuity was 1.34 logMAR with adaptive optics aberration correction; however, with purely refractive error corrections she was unable to identify the orientation of the gratings.

Conclusion: Correction of all aberrations using adaptive optics improves both high and low contrast resolution acuity at the PRL of a single low vision subject with longstanding absolute central scotoma.

Ort, förlag, år, upplaga, sidor
2012. Vol. 89, nr 9
Nationell ämneskategori
Oftalmologi
Identifikatorer
URN: urn:nbn:se:kth:diva-120074DOI: 10.1097/OPX.0b013e318264f2a7PubMedID: 22842306Scopus ID: 2-s2.0-84865730607OAI: oai:DiVA.org:kth-120074DiVA, id: diva2:613331
Anmärkning

QC 20130327

Tillgänglig från: 2013-03-27 Skapad: 2013-03-27 Senast uppdaterad: 2020-03-09Bibliografiskt granskad
Ingår i avhandling
1. Peripheral Vision: Adaptive Optics and Psychophysics
Öppna denna publikation i ny flik eller fönster >>Peripheral Vision: Adaptive Optics and Psychophysics
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

This thesis is about our peripheral vision. Peripheral vision is poor compared to central vision, due to both neural and optical factors. The optical factors include astigmatism, defocus and higher order aberrations consisting mainly of coma. Neurally, the density of ganglion cells decreases towards the periphery, which limits the sampling density. The questions that this thesis attempts to answer are how much and under which circumstances correction of optical errors can improve peripheral vision. For this, an adaptive optics system has been constructed with a wavefront sensor and a deformable mirror working in closed loop to perform real-time correction of optical errors. To investigate vision, psychophysical routines utilizing Bayesian methods have been evaluated and modified for peripheral vision to handle the presence of aliasing, fixation instability and rapid fatigue.

We found that correcting both refractive errors and higher order aberrations improved peripheral low-contrast resolution acuity. \\

We looked at two specific topics in peripheral vision research in particular: Central visual field loss and myopia development. Persons with central visual field loss have to rely on their remaining peripheral vision, and it is of great interest to understand whether optical correction can offer them any benefits. In a case study on a single subject, we found meaningful improvements in vision with both optimized refractive correction as well as additional benefits with aberration correction. These improvements were larger than for comparable healthy subjects with a similar magnitude of aberrations. When it comes to myopia development, an interesting hypothesis is that peripheral optics affect and guide the emmetropization process. We have found an asymmetric depth of field in the periphery for myopic subjects, caused by their higher order aberrations, and presented a model on how this asymmetry may influence the emmetropization process.

Ort, förlag, år, upplaga, sidor
Stockholm: KTH Royal Institute of Technology, 2013. s. xiii, 72
Serie
Trita-FYS, ISSN 0280-316X ; 2013:08
Nationell ämneskategori
Annan fysik
Identifikatorer
urn:nbn:se:kth:diva-120077 (URN)978-91-7501-698-6 (ISBN)
Disputation
2013-04-19, Sal FD5, AlbaNova Universitetscentrum, Roslagstullsbacken 21, Stockholm, 13:00 (Engelska)
Opponent
Handledare
Anmärkning

QC 20130327

Tillgänglig från: 2013-03-27 Skapad: 2013-03-27 Senast uppdaterad: 2013-04-12Bibliografiskt granskad

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