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Statistical Analysis of PAR-CLIP data
KTH, Skolan för datavetenskap och kommunikation (CSC), Beräkningsbiologi, CB.
2013 (Engelska)Självständigt arbete på avancerad nivå (masterexamen), 80 poäng / 120 hpStudentuppsats (Examensarbete)
Abstract [en]

From creation to its degradation, the RNA molecule is the action field of many binding proteins with different roles in regulation and RNA metabolism. Since these proteins are involved in a large number of processes, a variety of diseases are related to abnormalities occurring within the binding mechanisms. One of the experimental methods for detecting the binding sites of these proteins is PAR-CLIP built on the next generation sequencing technology. Due to its size and intrinsic noise, PAR-CLIP data analysis requires appropriate pre-processing and thorough statistical analysis.

The present work has two main goals. First, to develop a modular pipeline for preprocessing PAR-CLIP data and extracting necessary signals for further analysis. Second, to devise a novel statistical model in order to carry out inference about presence of protein binding sites based on the signals extracted in the pre-processing step. 

Ort, förlag, år, upplaga, sidor
2013. , s. 50
Nyckelord [en]
statistical modeling, PAR-CLIP, RNA-binding proteins, Bayesian analysis
Nationell ämneskategori
Bioinformatik och systembiologi
Identifikatorer
URN: urn:nbn:se:kth:diva-124337OAI: oai:DiVA.org:kth-124337DiVA, id: diva2:647525
Utbildningsprogram
Teknologie masterexamen - Systembiologi
Handledare
Examinatorer
Tillgänglig från: 2013-12-13 Skapad: 2013-06-28 Senast uppdaterad: 2022-06-23Bibliografiskt granskad

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