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Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks
KTH, Centra, Science for Life Laboratory, SciLifeLab. Novo Nordisk Foundation Center for Biosustainability.
2013 (Engelska)Ingår i: Current Opinion in Biotechnology, ISSN 0958-1669, E-ISSN 1879-0429, Vol. 24, nr 6, s. 965-972Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Bio-based production of chemical building blocks from renewable resources is an attractive alternative to petroleum-based platform chemicals. Metabolic pathway and strain engineering is the key element in constructing robust microbial chemical factories within the constraints of cost effective production. Here we discuss how the development of computational algorithms, novel modules and methods, omics-based techniques combined with modeling refinement are enabling reduction in development time and thus advance the field of industrial biotechnology. We further discuss how recent technological developments contribute to the development of novel cell factories for the production of the building block chemicals: adipic acid, succinic acid and 3-hydroxypropionic acid.

Ort, förlag, år, upplaga, sidor
2013. Vol. 24, nr 6, s. 965-972
Nyckelord [en]
3-Hydroxypropionic acid, Chemical building blocks, Computational algorithm, Cost-effective production, Industrial biotechnology, Strain engineering, Sustainable production, Technological development, Metabolic engineering, Metabolism, Indicators (chemical)
Nationell ämneskategori
Kemiteknik
Identifikatorer
URN: urn:nbn:se:kth:diva-139879DOI: 10.1016/j.copbio.2013.03.008ISI: 000328806200002Scopus ID: 2-s2.0-84887618970OAI: oai:DiVA.org:kth-139879DiVA, id: diva2:688790
Forskningsfinansiär
VinnovaKnut och Alice Wallenbergs StiftelseEU, Europeiska forskningsrådet, 247013Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Anmärkning

QC 20140117

Tillgänglig från: 2014-01-17 Skapad: 2014-01-15 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

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Nielsen, Jens
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Science for Life Laboratory, SciLifeLab
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Current Opinion in Biotechnology
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