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Optogenetic Stimulation in a Computational Model of the Basal Ganglia Biases Action Selection and Reward Prediction Error
KTH, Skolan för datavetenskap och kommunikation (CSC), Beräkningsbiologi, CB.
KTH, Skolan för datavetenskap och kommunikation (CSC), Beräkningsbiologi, CB.ORCID-id: 0000-0002-2358-7815
2014 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, nr 3, s. e90578-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Optogenetic stimulation of specific types of medium spiny neurons (MSNs) in the striatum has been shown to bias the selection of mice in a two choices task. This shift is dependent on the localisation and on the intensity of the stimulation but also on the recent reward history. We have implemented a way to simulate this increased activity produced by the optical flash in our computational model of the basal ganglia (BG). This abstract model features the direct and indirect pathways commonly described in biology, and a reward prediction pathway (RP). The framework is similar to Actor-Critic methods and to the ventral/ dorsal distinction in the striatum. We thus investigated the impact on the selection caused by an added stimulation in each of the three pathways. We were able to reproduce in our model the bias in action selection observed in mice. Our results also showed that biasing the reward prediction is sufficient to create a modification in the action selection. However, we had to increase the percentage of trials with stimulation relative to that in experiments in order to impact the selection. We found that increasing only the reward prediction had a different effect if the stimulation in RP was action dependent (only for a specific action) or not. We further looked at the evolution of the change in the weights depending on the stage of learning within a block. A bias in RP impacts the plasticity differently depending on that stage but also on the outcome. It remains to experimentally test how the dopaminergic neurons are affected by specific stimulations of neurons in the striatum and to relate data to predictions of our model.

sted, utgiver, år, opplag, sider
2014. Vol. 9, nr 3, s. e90578-
Emneord [en]
Dopamine Neurons, Corticostriatal Synapses, Dependent Plasticity, Synaptic Plasticity, Striatal Neurons, Cortex, Rat, Organization, Values, Roles
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-144545DOI: 10.1371/journal.pone.0090578ISI: 000332839300030Scopus ID: 2-s2.0-84897544915OAI: oai:DiVA.org:kth-144545DiVA, id: diva2:714386
Forskningsfinansiär
Swedish Research CouncilEU, FP7, Seventh Framework Programme, 237955 269921
Merknad

QC 20140428

Tilgjengelig fra: 2014-04-28 Laget: 2014-04-24 Sist oppdatert: 2018-01-11bibliografisk kontrollert

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