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The role of inhibition in generating and controlling Parkinson’s disease oscillations in the Basal Ganglia
University of Freiburg, Germany .ORCID-id: 0000-0002-8044-9195
2011 (engelsk)Inngår i: Frontiers in Systems Neuroscience, ISSN 1662-5137, E-ISSN 1662-5137, Vol. OCTOBER 2011, artikkel-id 86Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Movement disorders in Parkinson’s disease (PD) are commonly associated with slow oscillations and increased synchrony of neuronal activity in the basal ganglia. The neural mechanisms underlying this dynamic network dysfunction, however, are only poorly understood. Here, we show that the strength of inhibitory inputs from striatum to globus pallidus external (GPe) is a key parameter controlling oscillations in the basal ganglia. Specifically, the increase in striatal activity observed in PD is sufficient to unleash the oscillations in the basal ganglia. This finding allows us to propose a unified explanation for different phenomena: absence of oscillation in the healthy state of the basal ganglia, oscillations in dopamine-depleted state and quenching of oscillations under deep-brain-stimulation (DBS). These novel insights help us to better understand and optimize the function of DBS protocols. Furthermore, studying the model behavior under transient increase of activity of the striatal neurons projecting to the indirect pathway, we are able to account for both motor impairment in PD patients and for reduced response inhibition in DBS implanted patients.

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2011. Vol. OCTOBER 2011, artikkel-id 86
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URN: urn:nbn:se:kth:diva-154854DOI: 10.3389/fnsys.2011.00086PubMedID: 22028684Scopus ID: 2-s2.0-84862909305OAI: oai:DiVA.org:kth-154854DiVA, id: diva2:758924
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QC 20150429

Tilgjengelig fra: 2014-10-28 Laget: 2014-10-28 Sist oppdatert: 2018-01-11bibliografisk kontrollert

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