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Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery
KTH, Skolan för kemivetenskap (CHE), Kemi.
KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi. University of Massachusetts, United States.ORCID-id: 0000-0003-1121-4007
Visa övriga samt affilieringar
2015 (Engelska)Ingår i: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 51, nr 48, s. 9833-9836Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous glyconanoparticles has been developed and evaluated in normal- and cancer lung epithelial cells. The gating process proved efficient, exhibiting good sealing properties in the absence of the glutathione redox trigger, avoiding premature release in normal cells. In the presence of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the anticancer drug released.

Ort, förlag, år, upplaga, sidor
2015. Vol. 51, nr 48, s. 9833-9836
Nyckelord [en]
Silica Nanoparticles, Controlled-Release, Concanavalin-A, Nanocontainers, Nanocarriers, Biocompatibility, Covalent, Glucose, System, Cancer
Nationell ämneskategori
Kemi
Identifikatorer
URN: urn:nbn:se:kth:diva-169982DOI: 10.1039/c5cc02907dISI: 000355631700017PubMedID: 25989158Scopus ID: 2-s2.0-84930636671OAI: oai:DiVA.org:kth-169982DiVA, id: diva2:826480
Anmärkning

QC 20150625

Tillgänglig från: 2015-06-25 Skapad: 2015-06-25 Senast uppdaterad: 2017-12-04Bibliografiskt granskad
Ingår i avhandling
1. Multifunctional Glyconanomaterials: Applications in Biorecognition and Drug Delivery
Öppna denna publikation i ny flik eller fönster >>Multifunctional Glyconanomaterials: Applications in Biorecognition and Drug Delivery
2015 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

This thesis consists of three parts, which revolve around the fabrication of multifunctional glyconanomaterials (cellulose nanocrystals, chitin nanocrystals, mesoporous silica nanoparticles) and the development of their applications in biorecognition and nanomedicine.

Part one presents a detailed introduction to glyconanomaterials, focusing on cellulose nanocrystals, chitin nanocrystals and mesoporous silica nanoparticles, including their general preparations, properties and applications.

Part two demonstrates dually modified cellulose and chitin nanocrystals. They are prepared by TEMPO-mediated oxidation, followed by conjugation with a fluorescent dye and carbohydrate ligands. The two functional nanocrystals are applied in carbohydrate-lectin recognition and bacterial imaging as new types of glyconanomaterials.

Part three describes two types of drug delivery systems based on carbohydrate- conjugated mesoporous silica nanoparticles: the first type is a trehalose- functionalized nanoparticle which can selectively recognize mycobacteria, release antimicrobial drugs and kill them; the second type is a lectin-gated drug container, which can perform controlled delivery of drugs to cancer cells in response to glutathione.

Ort, förlag, år, upplaga, sidor
Stockholm: KTH Royal Institute of Technology, 2015. s. 70
Serie
TRITA-CHE-Report, ISSN 1654-1081 ; 2015:28
Nyckelord
glyconanomaterials, cellulose nanocrystals, chitin nanocrystals, mesoporous silica nanoparticles, lectin, biorecognition, drug delivery, bacteria, cytotoxicity, perfluorophenylazide, fluorescent dye, carbohydrate ligands.
Nationell ämneskategori
Nanoteknik
Identifikatorer
urn:nbn:se:kth:diva-171951 (URN)978-91-7595-570-4 (ISBN)
Disputation
2015-09-04, B2, Brinellvägen 23, KTH, Stockholm, 13:00 (Engelska)
Opponent
Handledare
Anmärkning

QC 20150813

Tillgänglig från: 2015-08-13 Skapad: 2015-08-10 Senast uppdaterad: 2015-08-13Bibliografiskt granskad

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Zhou, JuanYan, MingdiRamström, Olof
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