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Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue
KTH, Skolan för bioteknologi (BIO), Proteomik och nanobioteknologi. KTH, Centra, Science for Life Laboratory, SciLifeLab. Chalmers University of Technology, Sweden.
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2015 (Engelska)Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, artikel-id 14841Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Weight loss has been shown to significantly improve Adipose tissue (AT) function, however changes in AT gene expression profiles particularly in visceral AT (VAT) have not been systematically studied. Here, we tested the hypothesis that extensive weight loss in response to bariatric surgery (BS) causes AT gene expression changes, which may affect energy and lipid metabolism, inflammation and secretory function of AT. We assessed gene expression changes by whole genome expression chips in AT samples obtained from six morbidly obese individuals, who underwent a two step BS strategy with sleeve gastrectomy as initial and a Roux-en-Y gastric bypass as second step surgery after 12 +/- 2 months. Global gene expression differences in VAT and subcutaneous (S) AT were analyzed through the use of genome-scale metabolic model (GEM) for adipocytes. Significantly altered gene expressions were PCR-validated in 16 individuals, which also underwent a two-step surgery intervention. We found increased expression of cell death-inducing DFFA-like effector a (CIDEA), involved in formation of lipid droplets in both fat depots in response to significant weight loss. We observed that expression of the genes associated with metabolic reactions involved in NAD+, glutathione and branched chain amino acid metabolism are significantly increased in AT depots after surgery-induced weight loss.

Ort, förlag, år, upplaga, sidor
2015. Vol. 5, artikel-id 14841
Nationell ämneskategori
Biologiska vetenskaper
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URN: urn:nbn:se:kth:diva-175910DOI: 10.1038/srep14841ISI: 000362177200001PubMedID: 26434764Scopus ID: 2-s2.0-84943328195OAI: oai:DiVA.org:kth-175910DiVA, id: diva2:867130
Forskningsfinansiär
Knut och Alice Wallenbergs StiftelseEU, FP7, Sjunde ramprogrammet, HEALTH-F4-2012-305312Novo Nordisk
Anmärkning

QC 20151104

Tillgänglig från: 2015-11-04 Skapad: 2015-10-26 Senast uppdaterad: 2017-12-01Bibliografiskt granskad

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Mardinoglu, AdilNielsen, Jens
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Proteomik och nanobioteknologiScience for Life Laboratory, SciLifeLabGenteknologi
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