Concept design and In Vitro evaluation of a novel dynamic displacement Ventricular Assist Device
2006 (English)Licentiate thesis, monograph (Other scientific)
Ventricular Assist Devices (VADs) are mechanical pumps used to off-load a deceased heart, primarily in late stage congestive heart failure patients. VAD employment may facilitate cardiac recovery, but most often provides time before a suitable heart transplant can be found. Lately, long term use VAD systems have been introduced as an alternative to a heart transplant.
Traditionally, design of VADs has employed either displacement based pump technologies or radial-flow pumps, also known as rotodynamic pumps. A displacement pump induces a mechanical force on a fluid contained within a defined space, hence giving it motion. Radial-flow pumps impart momentum to a fluid, most often by placing a rotating device in the fluid.
This thesis introduces a novel pumping concept, combining features from both displacement and radial-flow pumps. A first prototype, the VivicorTM pump, has been designed, fabricated and evaluated In Vitro, the results reported in this thesis.
The In Vitro evaluation of the VivicorTM pump provides evidence of a pump with mechanical self-regulation based on pump pre-load level, much like a displacement pump. The VivicorTM pump also displays pulsating outflow in combination with an inflow both during pump systole and diastole. The latter provides potential advantages over traditional displacement pumps as smaller cannulae or catheters can be used, facilitating miniaturization. Continuos filling throughout the pumping cycle also require less pressure to be exerted on the fluid, compared to displacement pumps, limiting the risk of mechanical damage to the pumped fluid. The In Vitro evaluation has also provided further insights on necessary design modifications in the second-generation VivicorTM prototype, currently planned. The VivicorTM pumping technology is highly interesting for further development and evaluation for use in ventricular assist applications.
Place, publisher, year, edition, pages
Haninge: KTH Syd , 2006. , 99 p.
Trita-STH : report, ISSN 1653-3836 ; 2006:2
Ventricular Assist Devices, artificial heart, heart failure, InVitro evaluation
Medical Laboratory and Measurements Technologies
IdentifiersURN: urn:nbn:se:kth:diva-3991ISBN: 91-7178-320-2OAI: oai:DiVA.org:kth-3991DiVA: diva2:10286
2006-05-24, Seminarierummet, avd för medicinsk teknik, Novum, Karolinska univ.sjukhuset Huddinge, Huddinge, 14:00
Kjellman, Ulf, Docent
QC 201011292006-05-232006-05-232010-11-29Bibliographically approved