Multifunctional PLGA/Parylene C Coating for Implant Materials: An Integral Approach for Biointerface Optimization
2016 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 8, no 34, 22093-22105 p.Article in journal (Refereed) Published
Functionalizing implant surfaces is critical for improving their performance. An integrated approach was employed to develop a multifunctional implant:coating based on oxygen plasma-modified parylene C and drug-loaded, biodegradable poly(DL-lactide-co-glycolide) (PLGA). The key functional attributes of the coating (i.e., anti-corrosion, biocompatible, anti-infection, and therapeutic) were thoroughly characterized at each fabrication step by spectroscopic, microscopic, and biologic methods and at different scales, ranging from molecular, through the nano- and microscales to the macroscopic scale. The chemistry of each layer was demonstrated separately, and their mutual affinity was shown to be indispensable for the development of versatile coatings, for implant applications.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2016. Vol. 8, no 34, 22093-22105 p.
parylene C, coating, implant, biointerface, oxygen plasma, PLGA, MG-63, controlled drug elution
IdentifiersURN: urn:nbn:se:kth:diva-193201DOI: 10.1021/acsami.6b08025ISI: 000382514100030PubMedID: 27500860ScopusID: 2-s2.0-84984904303OAI: oai:DiVA.org:kth-193201DiVA: diva2:1033038
QC 201610052016-10-052016-09-302016-10-05Bibliographically approved