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Simultaneous Polymerization and Polypeptide Particle Production via Reactive Spray-Drying
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
2016 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 17, no 9, 2930-2936 p.Article in journal (Refereed) Published
Abstract [en]

A method for producing polypeptide particles via in situ polymerization of N-carboxyanhydrides during spray-drying has been developed. This method was enabled by the development of a fast and robust synthetic pathway to polypeptides using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an initiator for the ring-opening polymerization of N-carboxyanhydrides. The polymerizations finished within 5 s and proved to be very tolerant toward impurities such as amino acid salts and water. The formed particles were prepared by mixing the monomer, N-carboxyanhydride of L-glutamic acid benzyl ester (NCA(Glu)) and the initiator (DBU) during the atomization process in the spray-dryer and were spherical with a size of similar to 1 um. This method combines two steps; making it a straightforward process that facilitates the production of polypeptide particles. Hence, it furthers the use of spray-drying and polypeptide particles in the pharmaceutical industry.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2016. Vol. 17, no 9, 2930-2936 p.
Keyword [en]
Acid-N-Carboxyanhydrides, Ring-Opening Polymerization, Drug-Delivery, Poly(Lactic Acid), Block-Copolymers, Microparticles, Stability, Poly(Dl-Lactide-Co-Glycolide), Microencapsulation, Nanoparticles
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-194005DOI: 10.1021/acs.biomac.6b00747ISI: 000383213200017PubMedID: 27445061ScopusID: 2-s2.0-84986879566OAI: diva2:1037559
EU, European Research Council, 246776

QC 20161017

Available from: 2016-10-17 Created: 2016-10-14 Last updated: 2016-10-17Bibliographically approved

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