Simultaneous Polymerization and Polypeptide Particle Production via Reactive Spray-Drying
2016 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 17, no 9, 2930-2936 p.Article in journal (Refereed) Published
A method for producing polypeptide particles via in situ polymerization of N-carboxyanhydrides during spray-drying has been developed. This method was enabled by the development of a fast and robust synthetic pathway to polypeptides using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an initiator for the ring-opening polymerization of N-carboxyanhydrides. The polymerizations finished within 5 s and proved to be very tolerant toward impurities such as amino acid salts and water. The formed particles were prepared by mixing the monomer, N-carboxyanhydride of L-glutamic acid benzyl ester (NCA(Glu)) and the initiator (DBU) during the atomization process in the spray-dryer and were spherical with a size of similar to 1 um. This method combines two steps; making it a straightforward process that facilitates the production of polypeptide particles. Hence, it furthers the use of spray-drying and polypeptide particles in the pharmaceutical industry.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2016. Vol. 17, no 9, 2930-2936 p.
Acid-N-Carboxyanhydrides, Ring-Opening Polymerization, Drug-Delivery, Poly(Lactic Acid), Block-Copolymers, Microparticles, Stability, Poly(Dl-Lactide-Co-Glycolide), Microencapsulation, Nanoparticles
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:kth:diva-194005DOI: 10.1021/acs.biomac.6b00747ISI: 000383213200017PubMedID: 27445061ScopusID: 2-s2.0-84986879566OAI: oai:DiVA.org:kth-194005DiVA: diva2:1037559
FunderEU, European Research Council, 246776
QC 201610172016-10-172016-10-142016-10-17Bibliographically approved