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Spatially resolved gene expression analysis of dark CMM
KTH, School of Biotechnology (BIO).
2016 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Malignant melanoma is an aggressive type of skin cancer. High resistance to common therapies results in poor prognosis in later stages of the disease, which leaves early detection as crucial for patients’ survival. During the past decades, an increase in incidence of malignant melanoma has been observed worldwide. Majority of tumors shows heterogeneity and new analysis methods are needed for better understanding of cancer evolution. One such method is Spatial Trancriptomics.

Most melanoma biopsies contain dark, melanin-rich regions, which involves several challenges for the Spatial Transcriptomics technology. The aim of this project was to develop a protocol that allows for analysis of dark malignant melanoma tissue samples.

Place, publisher, year, edition, pages
2016.
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-190746OAI: oai:DiVA.org:kth-190746DiVA: diva2:1044142
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Available from: 2017-09-11 Created: 2016-08-15 Last updated: 2017-09-11Bibliographically approved

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