Change search
ReferencesLink to record
Permanent link

Direct link
Surface passivity largely governs the bioaccessibility of nickel-based powder particles at human exposure conditions
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science. Karolinska Institutet, Sweden.ORCID iD: 0000-0003-2145-3650
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science.ORCID iD: 0000-0002-2123-2201
Show others and affiliations
2016 (English)In: Regulatory toxicology and pharmacology, ISSN 0273-2300, E-ISSN 1096-0295, Vol. 81, 162-170 p.Article in journal (Refereed) Published
Abstract [en]

The European chemical framework REACH requires that hazards and risks posed by chemicals, including alloys and metals, are identified and proven safe for humans and the environment. Therefore, differences in bioaccessibility in terms of released metals in synthetic biological fluids (different pH (1.5–7.4) and composition) that are relevant for different human exposure routes (inhalation, ingestion, and dermal contact) have been assessed for powder particles of an alloy containing high levels of nickel (Inconel 718, 57 wt% nickel). This powder is compared with the bioaccessibility of two nickel-containing stainless steel powders (AISI 316L, 10–12% nickel) and with powders representing their main pure alloy constituents: two nickel metal powders (100% nickel), two iron metal powders and two chromium metal powders. X-ray photoelectron spectroscopy, microscopy, light scattering, and nitrogen absorption were employed for the particle and surface oxide characterization. Atomic absorption spectroscopy was used to quantify released amounts of metals in solution. Cytotoxicity (Alamar blue assay) and DNA damage (comet assay) of the Inconel powder were assessed following exposure of the human lung cell line A549, as well as its ability to generate reactive oxygen species (DCFH-DA assay). Despite its high nickel content, the Inconel alloy powder did not release any significant amounts of metals and did not induce any toxic response. It is concluded, that this is related to the high surface passivity of the Inconel powder governed by its chromium-rich surface oxide. Read-across from the pure metal constituents is hence not recommended either for this or any other passive alloy.

Place, publisher, year, edition, pages
Academic Press, 2016. Vol. 81, 162-170 p.
Keyword [en]
Alloy, Bioaccessibility, Inconel, Nickel, Toxicity
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:kth:diva-195212DOI: 10.1016/j.yrtph.2016.08.013ISI: 000389865600019ScopusID: 2-s2.0-84984813653OAI: diva2:1047654

QC 21061118

Available from: 2016-11-18 Created: 2016-11-02 Last updated: 2017-01-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Hedberg, YolandaHerting, GunillaOdnevall Wallinder, Inger
By organisation
Surface and Corrosion Science
In the same journal
Regulatory toxicology and pharmacology
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 1 hits
ReferencesLink to record
Permanent link

Direct link